大剂量甲基强的松龙治疗急性脊髓损伤疗效分析  

Curative Analysis on High Dose of Methyiprednisolone in Treating Acute Spinal Cord Injury

作　　者：闫德明 李亚伟[1] 刘拥军[1] 武军龙[1] 刘红军[1] 王殿欽 

机构地区：[1]洛阳市中心医院,河南洛阳471009

出　　处：《河南科技大学学报（医学版）》2009年第3期191-192,共2页Journal of Henan University of Science & Technology:Medical Science

摘　　要：目的研究大剂量甲基强的松龙(MP)治疗急性脊髓损伤的临床效果。方法对102例急性脊髓损伤患者,根据伤后时间并按自愿选择用药原则分为MP治疗组52例和对照组50例,以ASIA分级标准进行分级,并比较疗效和并发症。结果两组患者在治疗前后感觉及运动功能均有明显改善(P<0.05)。MP组的感觉及运动功能恢复均优于对照组(P<0.05)。MP治疗组中24 h治疗组与48 h治疗组并发症发生率比较无显著性差异(P>0.05),而MP组与对照组比较并发症的发生率明显增加,有显著性差异(P<0.05)。结论早期应用MP大剂量治疗急性脊髓损伤是一项有效措施,但会增加患者治疗中并发症的发生率。Objective To investigate the clinical effects of high dose of methyiprednisolone（MP） in the treatment of acute spinal cord injury（ASCI）. Methods In the retrospective study of 102 cases of ASCI, according to the period of injury and the principle of voluntary medication, patients were divided into MP group（52 cases）and control group （50 cases）, according to the classification of the American Spinal Cord Injury Association（ASIA） , patients were graded, and the curative effect and complication were compared. Results The sensation and neurological function improved significantly （ P 〈 0. 05 ）. The recovery of sensation and neurological function in MP group was superior to that in the control group （P 〈 0.05 ）. The comparism of the occurance rates of complications was not significantly different within 24 hours and 48 hours in MP group （ P 〈 0.05 ）. The occurance rate of the complications increased obviously and had significant difference in the MP group, as compared with that in control group （ P 〈 0.05 ）. Conclusion Earlier high dose of MP is an effective measure in treating ASCI, but can increase the occurance rate of complication in the treatment of patients.

关 键 词：脊髓损伤 甲基强的松龙 疗效分析 

分 类 号：R681.54[医药卫生—骨科学]