2型糖尿病大血管并发症与非高密度脂蛋白胆固醇关系的临床研究  

Relationship between non-high density lipoprotein cholesterol and macrovascular complications with type 2 diabetes mellitus

作　　者：王翠英[1] 贺彩果[1] 李涛[2] 

机构地区：[1]石家庄市第三医院内分泌科,河北石家庄050011 [2]河北医科大学流行病学教研室,河北石家庄050011

出　　处：《临床荟萃》2009年第20期1784-1786,共3页Clinical Focus

摘　　要：目的探讨非高密度脂蛋白胆固醇与2型糖尿病大血管并发症的关系及临床应用价值。方法选择2型糖尿病患者120例,分为糖尿病无大血管并发症组60例(B组),糖尿病大血管并发症组60例(C组),并选择正常对照组100例(A组),检测各组血脂并计算非高密度脂蛋白胆固醇(non-HDL-C),通过比较分析non-HDL-C与2型糖尿病大血管并发症的关系及临床应用价值。结果A组、B组、C组non-HDL-C水平依次升高,(3.04±0.62)mmol/L,(3.68±0.56)mmol/L vs(4.64±0.82)mmol/L(P<0.01);运用接收者工作特征(ROC)曲线对B、C组的血脂指标进行分析显示,C组non-HDL-C的曲线下面积最大,为0.845,且B、C两组间差异有统计学意义(P<0.01),临床应用价值较大。结论non-HDL-C的增高是糖尿病大血管并发症的危险因素,有较高的临床应用价值。Objective To explore the relationship of non-high density lipoprotein cholesterol（non-HDL-C） and macrovascular complications with type 2 diabetes mellitus（T2DM） and analyze the clinical application value of non-HDL C. Methods A total of 120 patients with T2DM were enrolled in the study：60 patients without macrovascular complications（group B）, 60 patients with macrovascular complications（group C）,meanwhile 100 individuals served as normal controls（group A）. Blood lipids were measured and non-HDL-C was calculated. Results The level of non- HDL-C was successively increased in group A, B and C, （3.04±0.62） mmol/L, （ 3.68±0.56） mmol/L vs （4.64±0.82） mmol/L（ P〈0. 01） ;Using receiver operator eharacteristic（ROC） curve to analyze the clinical application value of non-HDL-C in patients with maerovaseular eomplieations of T2DM,non-HDL-C had the largest area under-curve of 0. 845 in group C and had significant difference compared with group B（ P〈0.01）. Conclusion The increase of non- HDL-C is the risk factor for macrovascular complications of T2DM and has high clinical application value.

关 键 词：糖尿病 2型 血管疾病 胆固醇 脂代谢障碍 

分 类 号：R587.1[医药卫生—内分泌]