β受体信号系统对心力衰竭中心肌细胞凋亡的作用  

β-Adrenergic Receptor Signaling in Mediating Myocardial Apoptosis in Heart Failure

作　　者：孙峻峰[1] 富路[1] 

机构地区：[1]哈尔滨医科大学附属第一医院心内三科,黑龙江哈尔滨150001

出　　处：《心血管病学进展》2009年第5期853-855,共3页Advances in Cardiovascular Diseases

摘　　要：在胎儿期和生后发育早期心肌细胞的凋亡决定着成人心肌细胞数量。然而,成人心肌细胞明显有限的再生能力提示凋亡导致的心肌细胞的持续丢失可能促成了进展的心力衰竭。现着重阐述β受体信号系统在介导心肌细胞凋亡中的作用。Apoptosis of cardiac myocytes during fetal and early postnatal development may play a central role in determining the number of myocytes in the adult heart.However,the apparently limited capacity for regeneration of myocytes in the adult heart suggests that continued myocyte loss due to apoptosis could contribute to progressive heart failure.This article will focus on the potential role of β-adrenergic receptor signaling in mediating apoptosis in cardiac myocytes.

关 键 词：肾上腺素能受体 心力衰竭 

分 类 号：R541.61[医药卫生—心血管疾病] Q255[医药卫生—内科学]