两种具有杀线虫活性异戊烯基黄烷酮的全合成  

Total Synthesis of Two Nematicidal Prenylated Flavanones

作　　者：江世智[1] 杨金会[1] 赵艳敏[1] 李云峰[1] 计从斌[1] 刘万毅[1] 冀永强[1] 

机构地区：[1]宁夏大学能源化工重点实验室,宁夏银川750021

出　　处：《宁夏大学学报（自然科学版）》2009年第3期255-258,共4页Journal of Ningxia University(Natural Science Edition)

基　　金：教育部科学技术研究重点基金资助项目(203143);国家自然科学基金资助项目(20562010);宁夏自然科学基金资助项目(NZ0816)

摘　　要：以廉价的苯甲醛、对羟基苯甲醛和2-羟基苯乙酮为起始原料,经过C-异戊烯基化、酚羟基保护、羟醛缩合、催化环化、去保护基等步骤,合成了天然产物(±)-2,3-二氢-2-苯基-8-(3-甲基-丁基-2-烯基)-4H-1-苯并吡喃-4-酮及(±)-2,3-二氢-2-(4-羟苯基)-8-(3-甲基-丁基-2-烯基)-4H-1-苯并吡喃-4-酮,总收率分别为20%和16.3%.所有新化合物的结构都经过1HNMR,IR,MS确认.The total synthesis of（±）-8-（3-methylbut-2-enyl）-2-phenyl-2,3-dihydrochromen-4-one and（±）-2-（4-hydroxyphenyl）-8-（3-methylbut-2-enyl）-2,3-dihydrochromen-4-one were first achieved through C-prenylation,protection of phenolic hydroxyl group,aldol condensation,cyclization and deprotection starting from cheap benzaldehyde,4-hydroxybenzaldehyde and 2-hydroxyacetophenone,with the total yield of 20% and 16.3%.All structures of new compounds were confirmed by IR,1HNMR and MS.

关 键 词：线虫 黄烷酮 异戊烯基黄烷酮 全合成 

分 类 号：O625[理学—有机化学]