氟化物对骨细胞相关信号转导通路中各因子的影响研究  

The Effect of Fluorides on Each Factors of Bone Cell-Associated Signal Transduction Pathway

作　　者：胡伟婷[1] 程蔚[1] 孙婷婷[1] 

机构地区：[1]中国医科大学,沈阳110001

出　　处：《医学综述》2009年第19期2899-2902,共4页Medical Recapitulate

摘　　要：在氟化工业快速发展的同时,也影响了人类的生活。骨细胞相关信号转导通路是骨髓基质细胞向骨细胞分化调节中的重要环节,而氟化物能影响骨细胞相关信号转导通路中的各种因子,包括生长因子类、MAPK信号转导途径、钙元素、核因子κB受体活化因子等,从而影响其在骨细胞的增殖、分化、代谢、适应、防御和凋亡过程中的表达。本文主要就氟化物对各因子的影响机制进行综述。AS the fluoride industrial development rapidly, also affected the lives of human beings. The bone cell-associated signal transduction pathway is important part when bone marrow stromal cells change to the regulation of bone cell. Fluoride can affect the bone cell-associated signal transduction pathway which in- elude variety of factors, such as growth factors, MAPK signal transduetion pathway, calcium, receptor acti- vator of nuclear factor-KB and so on, thus affecting bone cell proliferation, differentiation, metabolism, ad- aptation, defense, and apoptosis during their expression. In this paper, the mechanism of these effects were reviewed.

关 键 词：氟化物 成骨细胞 破骨细胞 信号转导途径 

分 类 号：R12[医药卫生—环境卫生学]