缬沙坦氢氯噻嗪与缬沙坦对高血压患者左室肥厚及左室舒张功能的影响  

Effect of Valsartan/Hydrochlorothiazide and Valsartan on Left Ventricular Hypertrophy and Diastolic Function of Left Ventricular in Patients with Essential Hypertension

作　　者：曹东平[1] 彭应心[1] 姚文静[1] 李秀芳[1] 于薇[1] 容春莉[1] 

机构地区：[1]河北省人民医院,石家庄050051

出　　处：《中国循证医学杂志》2009年第9期953-956,共4页Chinese Journal of Evidence-based Medicine

摘　　要：目的观察缬沙坦氢氯噻嗪和缬沙坦对原发性高血压合并左室肥厚及左室舒张功能受损患者左室厚度及左室舒张功能的影响。方法将56例30～65岁原发性高血压合并左室肥厚和左室舒张功能受损患者随机分为两组,试验组28例,服用缬沙坦氢氯噻嗪(含缬沙坦80mg,氢氯噻嗪12.5mg),每日1次;对照组28例,服用缬沙坦80mg,每日1次。两组用药4周末如坐位舒张压≥12kPa或收缩压≥18.7kPa,剂量加倍,疗程均为6个月。结果治疗6个月末两组患者血压水平较治疗前均有明显下降(P<0.01),且两组间降压效果差异有统计学意义(P<0.05)。治疗6个月两组左室舒张功能指标、室间隔厚度、左室后壁厚度、左室重量及指数均明显降低(P<0.01),而左室射血分数则明显升高(P<0.01)。结论缬沙坦氢氯噻嗪不仅能有效降压,而且能更显著地改善左室肥厚和左室舒张功能。Objective To observe the effects of valsartan/hydrochlorothiazide and valsartan on left ventricular thickness and the left ventricular diastolic function in patients with essential hypertension and left ventricular hypertrophy and impaired left ventricular diastolic function.Methods 56 patients of essential hypertension with left ventricular hypertrophy and impaired left ventricular diastolic function were randomized into two randomized double-blind groups,valsartan/hydrochlorothiazide（HCTZ）80/12.5 mg o.d were gave to A group and valsartan 80 mg o.d were gave to B group. The dosage would be doubled in patients whose SDBP ≥ 12 kPa or SSBP ≥ 18.7 kPa after 4 weeks. Treatment lasted for 6 months. Result At the end of 6 months, valsartan/hydrochlorothiazide and valsartan significantly reduced BP from baseline （P〈0.01）, there was significant difference in reducing BP between the two groups （P〈0.05）. Indexes of left ventricular diastolic function （IVST, LVPWT, LVMI） significantly decreased （P〈0.01）. LVEF increased significantly （P〈0.01）. There was significant difference in IVST, LVPWT, LVMI and LVEF between two groups （P〈0.05）. Conclusion Valsartan/hydrochlorothiazide （HCTZ） can not only decrease blood pressure effectively, but also can significantly improve left ventricular hypertrophy and left ventricular diastolic function.

关 键 词：缬沙坦氢氯噻嗪 缬沙坦 高血压 左室肥厚 左室舒张功能 

分 类 号：R541.3[医药卫生—心血管疾病]