钯催化Suzuki交叉偶联反应合成2-(2′-萘基)噻唑  

Preparing 2-(naphthalen-2′-yl) thiazole by Pd-Catalyzed Suzuki cross-coupling reactions

作　　者：张罡[1] 王要令[1] 

机构地区：[1]河南城建学院化学化工系,河南平顶山467044

出　　处：《河南城建学院学报》2009年第4期24-25,41,共3页Journal of Henan University of Urban Construction

摘　　要：以2-萘硼酸和2-溴噻唑为原料,以Pd(PPh3)4为催化剂合成了2-(2′-萘基)噻唑,考察了不同的碱(K2CO3、Na2CO3、NaHCO3、NaOH、KOH、CH3COOK、t-(CH3)3COK)和不同的溶剂(Diox-ane、i-PrOH、DMF、Toluene、H2O、C2H5OH、THF)对该Suzuki偶联反应产率的影响。结果显示:2-萘硼酸和2-溴噻唑在溶剂为乙醇,乙酸钾为碱的时候得到的收率最高,且反应时间较短。2-（naphthalen-2′-yl） thiazole were synthesized by using 2-bromothiazole and naphtha-lene-2-ylboronic acid as raw materials,Pd（PPh3）4 as catalyst.The influences of different bases（such as K2CO3,Na2CO3,NaHCO3,NaOH KOH,CH3COOK,t-（CH3）3COK） and various solvents（including Dioxane,i-PrOH,DMF,Toluene,H2O,ethanol,and THF） on the Suzuki cross-coupling reaction were investigated.The results showed that the yield of the target product is the highest and the reaction time is short under the following reaction conditions;solvent is ethanol, base CH3COOK.

关 键 词：Pd(PPh3)4催化剂 Suzuki交叉偶联反应 2-萘硼酸 2-溴噻唑 

分 类 号：O543.36[理学—物理]