知母皂甙对动物甲状腺激素引起的异丙肾上腺素反应升高的调整作用及其机制  

The Regulative Effect of Timosaponin on Thyroxin_induced High Reactivity to Isoproterenol

作　　者：韩丽萍 赵树进[1,2,3] 胡本荣[1,2,3] 

机构地区：[1]广州军区后勤部药物研究所 [2]广州军区广州总医院 [3]中山医科大学药理教研室

出　　处：《中药新药与临床药理》1998年第4期224-226,共3页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：观察了知母皂甙对甲高模型动物β－受体系统的调整作用。发现异丙肾上腺素（ＩＳＯ）刺激甲高小鼠模型后的血浆环磷酸腺苷（ｃＡＭＰ）浓度显著高于对照组，知母皂甙对此具有保护作用。放射配基结合分析法观察甲高大鼠脑组织β－受体表观结合位点数（Ｒｔ），结果表明甲状腺激素可使β－受体的Ｒｔ值显著升高。The regulative effect of timosaponin on brain beta adrenoceptor system in mouse model with hyperthyroidism was observed. It was found that the concentration of plasma cAMP in mouse model with hyperthyroidism stimulated by isoproterenol was higher than that in the control group, and timosaponin showed a protective effect. Timosaponin could counteract the increase of the maximum binding capacities of brain beta adrenoceptors in rats with hyperthyroidism.

关 键 词：知母皂甙 药理学 Β受体 甲亢 

分 类 号：R285.5[医药卫生—中药学]