痰热清注射液对血浆IL-6及ACE影响及防治放射性肺炎疗效观察  

Clinical Observation of Tanreqing Injection's Influence on Changes of IL-6,ACE and Prevention of Radiation-induced Pulmonary Injure

作　　者：张静[1] 王晓红[1] 杨俊泉[1] 胡万宁[1] 张瑞娟[1] 

机构地区：[1]河北省唐山市人民医院放化疗科,河北唐山063000

出　　处：《实用预防医学》2009年第5期1537-1539,共3页Practical Preventive Medicine

基　　金：河北省中医药管理局立项课题[项目编号:05117(2005年)]

摘　　要：目的观察痰热清注射液对放疗后血浆中白介素-6(IL-6)及血管紧张素转换酶(ACE)含量影响以及对防治放射性肺炎的疗效。方法将88例肺癌患者随机分为两组,观察组45例放射治疗同时予痰热清注射液静滴,对照组43例只予常规放射治疗。放疗前及照射40～55Gy后分别采血冻存,采用酶联免疫吸附法检测血浆中IL-6及ACE含量。结果观察组放射性肺炎发生率17.78%(8/45),对照组37.21%(16/43);其中3、4级观察组为4.44%(2/45),对照组30.23%(13/43)(P<0.05)。观察组放疗前后IL-6分别为(9.13±3.72)和(7.57±2.22),对照组(8.76±2.87)和(10.50±4.00),放疗后两组差异有统计学意义(P<0.05)。观察组放疗前后ACE分别为(449.05±136.78)和(798.56±211.79),对照组为(494.00±203.79)和(132.37±58.38),放疗后两组差异有统计学意义(P<0.05)。结论痰热清注射液能降低血浆中IL-6的表达,能提高血浆中ACE的表达,有效预防和推迟严重性急性放射性肺炎的发生。Objective To observe the relationship between Tanreqing injection and the changes of plasma interleukin - 6 （IL- 6） and angiotensin- converting enzyme （ACE）, and to evaluate the therapeutic efficacy of Tanreqing injection in prevention of radiation - induced pulmonary injure. Methods Eighty- eight cases of lung cancers were divided into two groups randomly. 45 cases in the observation group were treated with intravenous drip of Tanreqing Injection combined with radiotherapy. Other 43 cases of the control group were treated with conventional radiotherapy. Blood specimens were taken from veins before radiation and after 40-55 Gy, for determination of the levels of IL - 6 and ACE in plasma by EL.ISA. Results The incidence rate of acute radiation pneumonitis was 17.78 % （8/45） in the observation group and 37.21% （16/43） in the control group. Grades 3 and 4 acute radiation pneumonitis occurred in 4.44 % （2/4.5） of the patients in the observation group, and 30.23 % （13/43） in the control group （P〈 0.05）. IL - 6 levels of the observation group in pre- and post- radiation 40 55 Gy were 9.13 ± 3.72 and 7.57 ± 2.22 pg/m, while in the control group 8.76 ± 2.87 and 10.50 ± 4.00 pg/m; there were statistically significant differences in the post- radiation between the two groups （P〈 0.0.5）. ACE levels of the observation group in pre - and post - radiation were 449.05 ± 136. ？8 and ？98.56± 211. 79, while in the control group 494.00 ± 203.79 and 132.37 ± 58.38 pg/m; there were statistically significant differences in the post- radiation between the two groups （P〈 0.05）. Conclusions Tanreqing injection could down- regulate IL - 6 expression and up - regulate ACE expression. Tanreqing injection is effective in preventing the occurrence of Grades 3-4 acute radiation pneumonitis.

关 键 词：肿瘤/放射疗法 放射性肺炎 细胞因子 痰热清注射液 

分 类 号：R563.1[医药卫生—呼吸系统]