ICU内洋葱伯克霍尔德菌感染的高危因素和耐药分析  

Risk Factors and Antibacterial Resistance Character of Burkholderia cepacia in Intensive Care Unit

作　　者：彭科[1] 张玉坤[1] 刘莉[1] 王扬[1] 

机构地区：[1]苏州大学附属第一医院麻醉科中心ICU,江苏苏州215006

出　　处：《实用预防医学》2009年第5期1544-1546,共3页Practical Preventive Medicine

摘　　要：目的研究重症监护病房(ICU)内洋葱伯克霍尔德菌感染的临床、药敏和危险因素。方法对ICU内病例进行回顾性分析,21例洋葱伯克霍尔德菌感染病例作为观察组,22例非洋葱伯克霍尔德菌病例作为对照组,用SPSS10.0软件统计分析其感染的危险因素。结果气管插管、气管切开,深静脉置管,使用抗生素≥7d,使用抗生素≥两种是主要的危险因素。洋葱伯克霍尔德菌具有多重耐药性,对头孢哌酮/舒巴坦、环丙沙星、哌拉西林/他唑巴坦敏感性较高,对丁胺卡那、亚胺培南的耐药率超过60%。结论减少侵入性操作和广谱抗生素的长期使用,根据药敏结果选用敏感抗菌药物,以减少洋葱伯克霍尔德菌感染的发生。Objective To study the clinical distribution, antimicrobial susceptibility, and risk factors of Burkholderia cepacia infection in intensive care unit （IOU）. Methods The clinical data of 21 cases with Burkholderia cepacia infection were retrospectively analyzed, and 22 cases with non Burkholderia cepacia infection served as control group. The risk factors of Burkholdeda cepacia infection were statistically analyzed by SPSS 10.0 software. Results Intubation, tracheotomy, deep venous catheterization, use of antibiotics≥7 days or 92 kinds were the risk factors. The bacterium was resistant to most antibiotics. The resistant rate of amikacin and imipenem was more than 60%, cefoperazone/sulbactam （71.4%）, ciprofloxaci （52.4%） and piperacillin/tazobactam （.52.4%） were higher susceptive. Conclusions The patients in ICU should be avoided invasive operation and the abuse of broad spectrum antibiotics for a long time. Bacterial culture and antibiotic susceptibility test must be carried out promptly.

关 键 词：重症监护病房 洋葱伯克霍尔德菌 高危因素 耐药性 

分 类 号：R378[医药卫生—病原生物学]