莫索尼啶致畸敏感期毒性试验研究  

Study on teratogenicity of moxonidine in mice

作　　者：张繁[1] 侯庆昌[1] 陈绮[1] 张娜[1] 

机构地区：[1]天津市计划生育研究所,天津300191

出　　处：《天津药学》1998年第4期16-18,共3页Tianjin Pharmacy

摘　　要：观察了莫索尼啶对小鼠致畸性影响。结果表明，莫索尼啶在0．3～3．0mg／kg剂量范围内，在妊娠小鼠致畸敏感期，连续口服给药不影响孕鼠生育能力；1．0～3．0mg／kg剂量范围内有明显的胚胎毒性，但对胎鼠外观、骨骼、内脏等无致畸作用。Teratogenicity was observed under the influence of moxonidine in mice, The results show that moxonidine administrated by oral during teratogenetic sensitive period in therange of 0.3~ 3.0mg/kg for 6~ l5 days seems not to affect reproductivity of pregnant mice,Although moxonidine had significant embryo toxicity in the range of 1.0~3.0 mg/kg it did notalso cause de formities of the fetal appearances,bone and internal organs.

关 键 词：莫索尼啶 致畸 小鼠 降压药 

分 类 号：R972.4[医药卫生—药品] R965.3[医药卫生—药学]