HLA-Cw与银屑病相关性的研究  

The study of the Association between HLA-Cw and Psoriasis

作　　者：朱明明[1,2] 普雄明[1,2] 吴卫东[1,2] 

机构地区：[1]石河子大学医学院,新疆石河子832002 [2]新疆维吾尔自治区人民医院附属皮肤性病科,新疆乌鲁木齐830001

出　　处：《现代生物医学进展》2009年第17期3345-3347,共3页Progress in Modern Biomedicine

基　　金：国家自然基金项目资助(30640056)

摘　　要：银屑病是一种多基因疾病,其原因尚未完全清楚。迄今为止,在OMIM中收录了七个银屑病易感基因位点,染色体6p上的PSORS1是当前银屑病的研究热点。PSORS1(银屑病易感基因1)对银屑病来说是一个主要的易感位点。目前将银屑病分为Ⅰ型和Ⅱ型,其中位于PSORS1上的HLA-Cw认为与Ⅰ型银屑病的联系最强。在以往的文献报道认为HLA-Cw与汉族银屑病患者的关系最为密切,但在新疆维吾尔族人中尚未发现这一相关性。Psoriasis is a Multi-gene disease, the reason of which is not clear. At present, there have 7 psoriasis predisposing genes locus in OMIM, the PSORS 1 on chromosomes 6p is the hot spot. PSORS 1 （psoriasis susceptibility gene 1） is a major susceptibility locus for psoriasis. Now psoriasis is derided into two type by the reseachers, type I and type . HLA-Cw of PSORS1 is considered to have the strongest relation with psoriasis type I in previous literature reports. Many reports show that HLA-Cw have the strongest relation with han patients with psoriasis in China, but this result has not been proved in Xi Jiang Uighurs.

关 键 词：银屑病 人类白细胞抗原 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]