卵泡发生过程中GDF-9和BMP-15(GDF-9B)的作用  

Role of GDF-9 and BMP-15 during folliculogenesis

作　　者：孙瑞珍[1] 程琳[2] 单智焱[2] 刘春佳[2] 张家新[1] 雷蕾[2] 刘忠华[3] 

机构地区：[1]内蒙古农业大学动物科学与医学学院,内蒙古呼和浩特市010018 [2]哈尔滨医科大学组织学与胚胎学教研室,黑龙江哈尔滨150081 [3]东北农业大学生命学院,黑龙江哈尔滨150031

出　　处：《现代生物医学进展》2009年第17期3351-3353,共3页Progress in Modern Biomedicine

基　　金：黑龙江省教育厅"新世纪"人才基金(1153-NCET-007)

摘　　要：近年来,对卵巢内卵泡发育,即从原始卵泡募集、优势选择、卵泡生长、排卵到黄体形成的调控研究取得了很大的进展。研究表明TGF-β超家族的许多成员在各阶段卵泡发生中起重要的调节作用。TGF-β超家族的两个成员--生长分化因子-9(GDF-9)和骨形态因子-15(BMP-15,或GDF-9B)主要在哺乳动物卵母细胞中表达,对卵泡生长发育起关键作用。本文对GDF-9和BMP-15在卵泡发育过程中的作用进行了综述。In recent years, regulations of ovary follicular development have made great progress on primordial follicle recruitment, selection, follicle growth, ovulation and formation of corpus luteum. Studies have showed that many of the members of transforming growth factor-β（TGF-β） superfamily play important roles in different stages of folliculogenesis. Growth differentiation factor 9 （GDF-9） and bone morphogenetic protein 15 （BMP-15）, two members of TGF-β superfamily, which mainly expressed in mammalian oocyte, play a key role in follicle growth and development. This review discussed the roles of GDF-9 and BMP-15 during follicular development.

关 键 词：GDF-9 BMP-15 卵泡发育 TGF-Β超家族 

分 类 号：Q492[生物学—生理学]