586例健康妇女HPV16、18型感染情况分析  

Analysis on the infection state of HPV16,18 in 586 normal women

作　　者：唐俭[1] 唐孝亮[1] 李修荣[1] 

机构地区：[1]湖南省怀化市第一人民医院检验科,418000

出　　处：《检验医学与临床》2009年第18期1521-1522,共2页Laboratory Medicine and Clinic

摘　　要：目的了解健康妇女人乳头瘤病毒(HPV)16、18型感染情况。方法采用实时荧光定量聚合酶链反应(FQ-PCR)对586例健康女性体检中的宫颈分泌物HPV16、18DNA进行检测。结果586例妇女宫颈分泌物共检出阳性61例,总阳性率为10.41%。按不同年龄段进行分组比较,各年龄组阳性检出率经χ2检验差异有统计学意义(χ2=130,P<0.01)。用χ2分割法进行两两比较,26～35岁与小于25岁两组间阳性检出率差异有统计学意义(χ2=7.11,P<0.05);26～35与36～45岁两组间差异有统计学意义(χ2=4.48,P<0.05);26～35与46～55岁两组间差异有统计学意义(χ2=11.32,P<0.05);其余各组两两比较差异均无统计学意义(P>0.05)。26～35岁与其他3个年龄组相比差异有统计学意义(χ2=12.54,P<0.05),其阳性检出率为16.28%,高于其他各年龄段。结论性活跃期女性感染HPV风险增加,应加强HPV监测与筛查。Objective To investigate the infection state of Human papillomavirus（HPV）-16,18 in the normal women at the local place. Methods Adopt the real time fluorogenic quantitative polymerase chain reaction（FQ- PCR） technique to carry on the examination of the cervix of the uterus secretion HPV16,18 DNA in the physical examination for the 586 normal feminie. Results The positive rates of HPV16,18 DNA was 10.41% （61/586）. By the comparison in accordence with the disparity in age section,masculine gender rate in the group with various age has the significance difference after the chi-square test （X^2 = 130, P〈0.01）. To compare, by dividing the law with X2, the group of 26-35 years old with the one with the age of older than 25, the rate of masculine genders has the significant difference （X^2 = 7. 11, P〈0. 05） ; It has the significant difference in group of 26 -35 years old, compared with the group of 36-45 year old women （X^2 =4.48,P〈0.05）; the group of 26-35 year old has the significant difference, compared with the group of 46-55 year old （X^2 = 11.32,P〈0.05） ; The other groups do not have any significant difference with each other （P〉0.05）. the group of 26-35 year old,compared with other three different age groups,＇ has the significant difference （X^2 = 12.54,P〈0.05）, and its masculine gender rate is 16.28%, which is higher than that of other various age section. Conclusion In the natural active phase female latent exposition in front of HPV, the infection risk increases. So HPV monitor should be strengthened to sieve and detect the disease.

关 键 词：人乳头瘤病毒 宫颈癌 实时荧光定量聚合酶链反应法 

分 类 号：R711.74[医药卫生—妇产科学]