心钠素对急性呼吸困难的诊断和鉴别诊断意义  

The diagnostic value of atrial natriuretic polypeptide levels in patients with acute dyspnea

作　　者：张红[1] 张丽英[1] 曲雷[1] 尚少红[1] 朱京炜 李湘[1] 王子红[1] 

机构地区：[1]北京市石景山医院急诊科,北京100043

出　　处：《临床急诊杂志》2009年第5期266-267,共2页Journal of Clinical Emergency

摘　　要：目的:探讨心钠素在急性呼吸困难中的诊断和鉴别诊断意义。方法:急性呼吸困难患者110例,测定血浆心钠素水平,以ANP=0.29pg/L为阳性界定值对其诊断心衰的价值进行评价。结果:心衰患者ANP明显高于非心衰患者,以ANP=0.29pg/L为阳性界定值,ANP诊断心源性呼吸困难的敏感性为95.00%,特异性为88.64%,阳性预测值为86.36%,阴性预测值为95.12%。结论:ANP对于诊断和鉴别诊断急性呼吸困难,具有重要意义。Objective：To investigate the diagnostic value of atrial natriuretic polypeptide （ANP） levels in patients with acute dyspnea. Method： 110 patients with acute dyspnea were admitted in our study. The plasma level of ANP was measured and analyzed. Result：The plasma level of ANP in patients with heart failure was significant higher than that in patients without heart failure（ P d0.05）. The sensitivity and specificity of plasma ANP measurement with a cut-off value of 0.29 ng/ml in patients with heart failure in differential diagnosis for acute dyspnea were 95.00% and 88. 64%. The positive predictive value and the negative predictive value were 86. 36% and 95.12% respectively. Conclusion：The plasma level of ANP has great clinical significance in differential diagnosis for patients with acute dyspnea.

关 键 词：呼吸困难 心力衰竭 心钠素 

分 类 号：R441.8[医药卫生—诊断学]