小剂量米非司酮配伍依沙吖啶用于中期妊娠引产  

Clinical observation of low-dosage mifepristone in combination with rivanol on induction of labor in mid-pregnancy

作　　者：白雪梅[1] 郭宗芳 李莹[1] 

机构地区：[1]山东省淄博市第八人民医院,255026

出　　处：《中国实用医药》2009年第29期21-22,共2页China Practical Medicine

摘　　要：目的探讨小剂量米非司酮配伍依沙吖啶用于中期妊娠引产的临床效果、对产程的影响。方法100例孕16～26周的妇女随机分成两组米非司酮配伍依沙吖啶组(观察组)和依沙吖啶+安慰剂组(对照组),观察组羊膜腔内注入依沙吖啶100 mg后,间隔12 h口服米非司酮各25 mg,对照组注药后口服安慰剂,服法同米非司酮。观察两组分娩痛的程度、胎儿胎盘娩出时间、总产程、清宫时组织残留量、产后出血量、宫颈裂伤发生率。结果观察组产痛评分低于对照组,但两组比较差异无统计学意义(P>0.05);观察组的胎儿胎盘娩出时间、总产程较对照组短,清宫时胎盘胎膜残留量少于对照组,差异有统计学意义(P<0.05);产后出血量观察组少于对照组,但两组比较差异无统计学意义(P>0.05)。两组均未出现宫颈裂伤。结论小剂量米非司酮配伍依沙吖啶引产能缩短引产时间,减轻引产孕妇的痛苦,减少胎盘胎膜的残留,是一种较好的中期妊娠引产方法。Objective To determine the efficacy and the effect of delivery process for induction of labor in mid-pregnancg using low-dosage of mifepriatonein in combination with rivanol. Methods 100 women seeking termination of the pregnancy（ 16-26 weeks）were allocated equally into two groups randomly. The 50 women of the observational group were administered 100 mg rivanol intra-amniotic cavity and were given orally 25 mg mifepristone two times with 24 hoursinterval. Another 50 women of the control group were administered 100 mg rivanol intra-amniotie and were given a matching placebo. The degree of labor pains, the ejection time of fetus and placenta, total stage of labor, the injury of soft birth canal, the amount of placenta and fetal membranes retention, quantity of postpartum hemorrhage were compared between the two groups. Results The score of labor pains in the observational group was lower than that in the control one and no significant differences between two groups （ P 〉 0. 05 ）. The following situation of observational group were lower than the control group（ P 〈 0.05 ）, including the ejection time of fetus and placenta, total stage of labor, the amount of placenta and fetal membranes retention. Conclusion The usage of mifepristone in combination with rivanol in induction of labor can be recommended for its promotion of birth process and less pain of induted labor and reduction of placenta and embryolemma residual.

关 键 词：米非司酮 依沙吖啶 中期妊娠 引产 

分 类 号：R719.3[医药卫生—妇产科学]