恩诺沙星口服混悬液的研制及其对仔猪黄白痢疗的效观察  

Study on Preparation of Enroofloxacin Oral Suspension and Its Effect on in Treating the Yellow and White Cours of Piglets

作　　者：刘小艳[1] 方炳虎[2] 杨利军[1] 袁照红 

机构地区：[1]广东大华农动物保健品股份有限公司,广东新兴527400 [2]华南农业大学兽医学院,广东广州510642

出　　处：《动物医学进展》2009年第9期120-122,共3页Progress In Veterinary Medicine

摘　　要：以恩诺沙星为原料,纯化水为溶媒,利用胶体磨采用分散法研制出恩诺沙星口服混悬液,并对制剂进行了稳定性研究。结果显示,所有参试样品的外观性状、沉降体积比、再分散性、相对含量等指标均无明显变化,表明该制剂稳定性良好。结果表明,试验组与对照组对仔猪黄白痢的治愈率分别为72.0%和66.0%,有效率分别为92.0%和72.0%,试验组对仔猪黄白痢的有效率与对照组比较差异极显著(P<0.01),表明恩诺沙星口服混悬液对仔猪黄白痢的临床疗效显著优于恩诺沙星溶液。Enroofloxacin oral suspension was developed successfully by using colloidmill to suspend the enroofloxacin in purified water in this study. The enroofloxacin concent rations of preparation samples were determined by HPLC. The preparation was carried on a stability test. At the end of the test,all items such as color,the ratio of settling volume,redispersibility,content were no significant changes. The experimental results indicated that the oral suspension was stable. For verifying the clinical effects of enroofloxacin oral suspension on controlling the yellow and white scour of piglets, natural sick piglets suffered from yellow and white scours were selected for the test,and the piglets treated with enroofloxacin solution were used as the control. The results showed that the cure rates of the piglets in the experimental group and the control group were 72.0% and 66.0% ,respectively. The effective rates were 92.0% and 72.0%,respectively. The difference of cure rate between the experimental group and the control group was significant （P 〈0.01）. The results indicated that the effects of enroofloxacin oral suspension on curing the yellow and white scours of piglets were better than that of the enroofloxacin solution.

关 键 词：恩诺沙星 口服混悬液 仔猪黄白痢 

分 类 号：S859.7[农业科学—临床兽医学]