61例儿童甲状腺功能亢进症临床治疗  

The Analysis of the Clinical Treatment of Hyperthyroidism Children of 61 Cases

作　　者：王德亮[1] 齐风芹[1] 

机构地区：[1]聊城市第二人民医院小儿科,临清252600

出　　处：《中国医疗前沿》2009年第18期49-50,共2页China Healthcare Innovation

摘　　要：目的探讨儿童甲状腺功能亢进症的治疗措施及临床效果。方法对入选的61例儿童甲状腺功能亢进症患儿给予他巴唑0.5～1mg/(kg·d)治疗,2～3个月后,当患儿甲状腺功能基本恢复正常后,将患儿随机分为对照组(n=31)及研究组(n=30),对照组继续给予他巴唑治疗,研究组给予他巴唑联合左甲状腺素治疗,在治疗前、治疗后第2个月、第6个月和1年时比较患儿甲状腺体积,FT4、FT3、TSH。治疗2年后观察临床疗效及不良反应发生情况。结果治疗6个月后,研究组甲状腺体积明显降低(P<0.05),药物性甲状腺功能减退症发生率低(P<0.05),有显著性差异,不良反应发生少。结论两组治疗均能有效改善儿童甲状腺功能亢进症的高代谢症候群,使TSH、FT4、FT3恢复正常,但他巴唑联合左甲状腺素治疗更能安全有效控制甲状腺肿大及药物继发性甲状腺功能减退症,并能减少症状复发。Objective Explore the children of hyperthyroidism and clinical effects of treatment. Methods Selected 61 casesof hyperthyroidism children in the treatment of children began to give tapazole 0.5～1mg / （kg·d） treatment, 2 to 3 months later,when children with thyroid function returned to normal after suffering from infants were randomly divided into control group （n=31）and Study Group （n=30）, the control group continued methimazole treatment, study group co-tapazole levothyroxine treatment,before treatment, after treatment 2 months, 6 months and 1 year compared to children with thyroid volume, FT4, FT3, TSH. 2 years after treatment to observe the clinical efficacy and the occurrence of adverse reactions. Results 6 months after treatment, the Study Group of thyroid volume decreased significantly （P〈0.05）, drug-induced hypothyroidism with low incidence （P〈0.05）, there were significant differences in fewer adverse events. Conclusion The two groups can be effective in improving the treatment of hyperthyroidism children of high metabolic syndrome, so that TSH, FT4, FT3 back to normal, but the joint tapazole levothyroxine treatment more safe and effective control of goiter and thyroid function secondary drug Hypothyroidism and can reduce the recurrence of symptoms.

关 键 词：儿童甲状腺功能亢进症 他巴唑 左甲状腺素 

分 类 号：R581.1[医药卫生—内分泌] R725.8[医药卫生—内科学]