成都地区孕母血型抗体效价分布及其与新生儿溶血病的相关性分析  

THE DISTRIBUTION OF MATERNAL BLOOD GROUP ANTIBODY TITER AND ITS CORRELATION WITH HEMOLYTIC DISEASE OF NEWBORN IN CHENGDU

作　　者：陈新敏[1] 雷萍[1] 罗红权[1] 倪雪梅[1] 吴雨露[1] 蒋敏[2] 

机构地区：[1]四川省妇幼保健院,成都610031 [2]四川大学华西第二医院人类精子库

出　　处：《现代预防医学》2009年第19期3618-3619,共2页Modern Preventive Medicine

摘　　要：[目的]了解成都地区孕妇血清中血型抗体效价的分布及其与新生儿溶血病(HDN)发病率间的关系。[方法]采用微柱凝胶法,对765例O型孕母血清血型抗体效价进行检测,并对其中60例有HDN危险的孕妇所生新生儿进行HDN血型血清学检测(ABO血型鉴定、直接抗人球蛋白试验、游离抗体测定及放散试验)。[结果]765例O型孕母血清IgG抗A(B)效价≥1︰64者315例,占41.2%;60例母婴血型不合且有ABO-HDN危险的孕妇所生新生儿中共有29例发生ABO-HDN;孕母血清IgG抗A(B)效价为﹤1︰64、1︰64、1︰128、≥1︰256,各组HDN阳性率分别为18.5%、46.6%、93.3%、100%。[结论]孕母血清中血型抗体效价与ABO-HDN的发病率成正相关,且若抗体效价随孕周增加而增高,则新生儿患HDN的概率也增加。产前检测孕母血清血型抗体效价对预测新生儿溶血病的发生具有重要的意义。[ Objective ] To study the distribution of maternal bloat group antibody titer and the correlation with hemolytic disease of newborn in Chengdu. [Methods] Blood group antibody titers of 765 pregnant women with type O were detected by microcolumn gel technique; after birth, blood type, Coombs test, free antibody and antibody release test were done for those 60 babies who were at high risk of HDN. [ Results] There were 315 women whose antibody titers≥1 ： 64, which accounted for 41.2% of all; And 29 babies suffered from HDN in those 60 babies; the anti-A （B） IgG titer of maternal serums was 〈 1 ： 64, 1 ： 64, 1 ： 128 and ≥1 ： 256, HDN positive rate was 18.5%, 46.6%, 93.3% and 100%, respectively. [Conclusion ] There is a positive eorrelation between blood group antibody titer and HDN. It is significant for pregnant women to detect the blood group antibody.

关 键 词：血型抗体 新生儿溶血病 产前检查 

分 类 号：R556.63[医药卫生—血液循环系统疾病]