Clean synthesis of calix[4]crown-5-sulfonyl cyclothiourea derivatives at room temperature in aqueous solution  

作　　者：Cong Wen Ding Ming Jie Zhang Ning Ma 

机构地区：[1]Chemistry Department of Science School, Tianjin University, Tianjin 300072, China

出　　处：《Chinese Chemical Letters》2009年第10期1166-1169,共4页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(No.20802049) and Program for New Century Excellent Talents in University of Tianjin City

摘　　要：Calix[4]-crown-5-sulfonyl cyclothiourea derivatives 6 and 7 were synthesized from calix[4]-crown-5-monosulfonylethylenediamine derivatives 4 and 5 and carbon disulfide through nucleophilic addition and subsequent cyclization of intramolecule at room temperature in aqueous solution. The advantages of the novel protocol are the mild reaction condition, free organic solvent, simple final treatment, easy isolation of products and excellent yields.Calix[4]-crown-5-sulfonyl cyclothiourea derivatives 6 and 7 were synthesized from calix[4]-crown-5-monosulfonylethylenediamine derivatives 4 and 5 and carbon disulfide through nucleophilic addition and subsequent cyclization of intramolecule at room temperature in aqueous solution. The advantages of the novel protocol are the mild reaction condition, free organic solvent, simple final treatment, easy isolation of products and excellent yields.

关 键 词：Room temperature Aqueous solution -crown-5-sttlfonyl cyclothiourea Clean synthesis 

分 类 号：O636.1[理学—高分子化学] TQ225.146[理学—化学]