An improved synthesis of (-)-7-isopropyl-cis-l-amino-2-indanol the chiral auxiliary for 6π-azaelectrocyclization  

作　　者：Su Yun Liu Shigeo Katsumura 

机构地区：[1]Beijing Collab Pharma Co. Ltd., No. 26 Jinyuan Street, Daxing Industrial Development Area, Beijing 102600, China [2]School of Science and Technology, Kwansei Gakuin University, Gakuen 2-1, Sanda, Hyogo 669--1337, Japan

出　　处：《Chinese Chemical Letters》2009年第10期1204-1206,共3页中国化学快报（英文版）

摘　　要：（-）-7-Isopropyl-cis-l-amino-2-indanol, a key chiral auxiliary and ligand in the highly stereo-selective asymmetric 6π- azaelectrocyclization, has been prepared previously by two methods. Each however involved using of one extreme condition, i.e. high temperature or high pressure, for the respective reaction. A modified reaction route employed mild condition for synthesis was presented in this report.（-）-7-Isopropyl-cis-l-amino-2-indanol, a key chiral auxiliary and ligand in the highly stereo-selective asymmetric 6π- azaelectrocyclization, has been prepared previously by two methods. Each however involved using of one extreme condition, i.e. high temperature or high pressure, for the respective reaction. A modified reaction route employed mild condition for synthesis was presented in this report.

关 键 词：CHIRAL cis-1-Amino-2-indanol Asymmetric dihydroxylation 

分 类 号：O621.34[理学—有机化学] TQ560.6[理学—化学]