固醇转运蛋白SCP-2研究进展  

A review of research on sterol carrier protein-2

作　　者：陈苗[1] 艾雪[1] 金松恒[1] 江敏利 郑炳松[1] 

机构地区：[1]浙江林学院浙江省现代森林培育技术重点实验室,浙江临安311300 [2]浙江省温岭市箬横镇人民政府,浙江温岭317507

出　　处：《浙江林学院学报》2009年第5期735-741,共7页Journal of Zhejiang Forestry College

基　　金：浙江省自然科学基金资助项目(Y305314);浙江省留学回国基金资助项目(2261000026);浙江林学院科学研究发展基金;浙江省森林培育重中之重学科开放基金资助项目(200514)

摘　　要：固醇转运蛋白(SCP-2,也称非特异性脂类转移蛋白)是一类碱性小分子蛋白质,存在于过氧化物酶体中,在体外可以增强质膜间胆固醇和脂类的运输,广泛存在于细菌、古细菌和真核生物中。大量的研究表明,它与多种物质的代谢过程有关,但由于它复杂的结构和功能,其具体作用机制目前仍未被明确阐述。为此,作者着重以真核生物SCP-2家族为例,介绍了SCP-2结构域的进化、结构与功能近年来的研究进展,并对SCP-2基因家族及SCP-2蛋白应用前景作了论述。Sterol carrier protein-2 （SCP-2,also known as the non-specific lipid transfer protein） is an in-tracellular,small,basic protein domain that in vitro enhances the transfer of lipids and sterol between membranes. It is widely existed in bacteria,archaea,and eukaryotes. The roles of SCP-2 remain unclear owing to its complicated structure and function although there are suggestions that SCP-2 involves in catalyzing metabolism of plentiful matters. The purpose of this review is to summarize our current knowledge about evolution, structure and function of the eukaryotic SCP-2 gene family and discuss potential functions of SCP-2 in vivo or vitro as studied in large numbers of experiments in recent years. Furthermore, the SCP- 2 gene and the application of SCP-2 are discussed.

关 键 词：生物化学 固醇转运蛋白 分子结构 功能 

分 类 号：Q513[生物学—生物化学] S718.43[农业科学—林学]