不同时间服用苯那普利对非勺型高血压的降压效果  

Effect of benazepril with defferent dose and time on blood pressure diurnal rhythm in patients with non-dipper hypertension

作　　者：马英[1] 朱飞奇[2] 冮洪生 

机构地区：[1]湖北省十堰市人民医院心内科,湖北十堰442000 [2]湖北省十堰市太和医院

出　　处：《心血管康复医学杂志》2009年第5期478-480,482,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察不同时间给药对非勺型高血压患者血压昼夜节律的影响。方法:选择80例经24h动态血压监测(ABPM),属非勺型的轻中度原发性高血压患者,随机均分为对照组、治疗组,对照组上午7时服用苯那普利10mg,治疗组上午7时和晚上7时各服用苯那普利5mg。给药6周后复测ABPM。比较两组血压昼夜节律的变化。结果:两组治疗后24h,白昼、夜间平均收缩压、舒张压,均显著下降(P<0.01),且治疗组的夜间平均收缩压[(121.3±4.9)mmHg]、舒张压[(77.6±8.0)mmHg],白昼、夜间血压负荷[(12.7±9.6)%,(8.5±6.7)%]较对照组显著下降(P<0.05)。对照组和治疗组血压昼夜节律改变有效率分别为SBP48.65%和77.78%;DBP45.95%和72.22%,有显著性差异(P<0.01)。结论:对于非勺型高血压,苯那普利分为早晚两次服用,可以更好改变血压昼夜节律,从而达到保护靶器官的目的。Objective： To observe the effect of benazepril with defferent dose and time on blood pressure diurnal rhythm in patients with non-dipper hypertension. Methods： A total of 80 patients with mild to moderate essential hypertension （EH） were randomly divided into two groups： the patients of control group were treated with 10rag benazepril at 7AM, and treatment group were with 5mg at 7AM and 5mg at 7PM. The change of 24h BP and blood pressure diurnal rhythm before treatment and 6 weeks later were compared. Results： The 24h, day, and night average SBP, DBP of two groups all significantly decreased （P〈0. 01 all）. The night average SBP [ （121.3±4. 9） mmHg], DBP [ （77.6±8. 0） mmHg], day load of blood pressure [dLBP （12.7 ± 9. 6） %], night load of blood pressure [nLBP （8.5 ± 6.7） %] of treatment group significantly decreased compared with those of control group （P〈0.05 all）. Compared with control group, the effectiveness rates of diurnal rhythm of SBP （48.65% vs. 77.78%） and DBP （45.95% vs. 72.22 % ） of treatment group significantly increased （P 〈 0. 01 all）. Conclusion： Benazepril can effectively decrease the blood pressure day-night rhythm in patients with non--dipper hypertension by taken 5 mg twice a day.

关 键 词：高血压 苯那普利 心电描记术 便携式 

分 类 号：R544.1[医药卫生—心血管疾病]