交联型温度/pH双敏水凝胶的设计与制备  

Design and Preparation of Temperature/pH Dual-Responsive Cross-linked Hydrogels

作　　者：孙希孟[1,2] 石军[1] 曹少魁[1] 

机构地区：[1]郑州大学材料科学与工程学院,郑州450052 [2]郑州大学化学系,郑州450052

出　　处：《高分子通报》2009年第10期30-37,共8页Polymer Bulletin

基　　金：国家自然科学基金项目资助(No.20874090)

摘　　要：刺激响应型水凝胶是其结构和性能随环境条件的变化而发生改变的一类智能高分子材料。由于温度和pH值是生物和化学系统的两个重要因素,也是人体的重要生理指标,因此温度/pH双重响应型水凝胶的制备及其在医药领域的应用研究具有重要的理论和现实意义。论文综述了近年来国内外温度/pH双敏水凝胶的设计与制备方法,并对其制备与应用的发展方向进行展望。Stimulus-responsive hydrogels are defined as intellect polymeric materials that undergo physical or chemical changes in response to small external changes in the environmental conditions. Whereas temperature/pH dual-responsive hydrogels have been extensively investigated in the biomedical field because these two factors can be easily controlled and realized both in vitro and in vivo conditions. This review focuses on the recent development of three cross-linked-type dual-responsive hydrogels ： copolymer-type, grafted-type and IPN-type. The prospects of these intelligent hydrogels in biomedical field are also discussed.

关 键 词：智能水凝胶 温度/pH响应 共聚 接枝 互穿聚合物网络(IPN) 

分 类 号：O648.17[理学—物理化学] TQ633[理学—化学]