ACEI联合ARB治疗老年糖尿病肾病的临床观察  

Clinical Observation of Treating Diabetes Nephropathy in Elderly by ACEI Combined With ARB

作　　者：沈慧[1] 姜红[1] 刘正荣[1] 

机构地区：[1]成都市第七人民医院,四川成都610021

出　　处：《现代临床医学》2009年第5期337-338,共2页Journal of Modern Clinical Medicine

摘　　要：目的:观察比较血管紧张素转换酶抑制剂(ACEI)和血管紧张素受体拮抗剂(ARB)联合应用与单用ACEI或ARB治疗老年糖尿病肾病的疗效。方法:将确诊为糖尿病肾病(DN)老年患者60名随机分为ACEI组19例、ARB组18例、ACEI+ARB联合用药组23例。比较观察治疗2个月后3组患者血压、血肌酐、尿白蛋白排泄率(urinary albuminexcretion rate,UAER)、电解质(钾离子)的变化。结果:各治疗组治疗后血压及尿蛋白排泄率均下降(P<0.05),但联合用药组疗效明显高于ACEI组和ARB组(P<0.05)。结论:对老年糖尿病患者,与单用ACEI或ARB比较,ACEI与ARB联合治疗糖尿病肾病可提高降压效果并明显降低蛋白尿,且副作用小,故联合ACEI及ARB是安全有效治疗方法。Objective：To compare with curative effects between combining ARB and ACEI and single ACEI or ARB on type -2 diabetes renal proteinuria in elderly. Methods：patients were ramdomly divided into A or B or C groups. The patients in group A were treated with ACEI, The patients in group B were treated with ARB, The patients in group C were treated with ACEI and ARB. 2 months later UAER, blood pressure, serum creatinine , electrolyte （ K ^＋） were observed before and after treatment. Results ： after 2 months treatment, The UAER and blood pressure were lowered in three groups than before treatment , especially in group C. Conclusion：The combination of ACEI with ARB has better renal protective effects on elder DN patients than ACEI or ARB alone, can decrease obviously 24 hour proteinuria levels.

关 键 词：ACEI ARB 老年 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]