痛风膏治疗痛风的临床观察  

Clinical Observe on Gout Ointment in Treating Gout

作　　者：丁庆余[1] 宋恩峰[1] 任开明[1] 胡家才[1] 程虹[1] 

机构地区：[1]武汉大学人民医院中西医结合科,武汉430060

出　　处：《中国中医骨伤科杂志》2009年第10期20-22,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：湖北省科技厅攻关课题(301130802)

摘　　要：目的:研究痛风膏对痛风的治疗效果。方法:将100例痛风患者随机分为2组。对照组:痛风定胶囊2粒/次,3次/d.治疗组:在对照组基础上,用中药痛风膏外敷,2次/d。2周为1疗程,共治疗2个疗程。观察止痛时间。血β2-M、血红蛋白、24h尿蛋白、血尿酸、肾功能等指标的变化。结果::①治疗组血β2-M显著下降(P<0.01),对照组无变化(P>0.05),治疗组血红蛋白较治疗前明显改善(P<0.01),24h尿蛋白治疗组治疗后有显著改善(P<0.01),对照组前后比较差异无统计学意义(P>0.05),两组均能改善尿液pH值(P<0.01)。组间比较差异无统计学意义(P>0.05)。②两组均能降低血尿酸、BUN、Scr(P<0.01),但两组比较差异有统计学意义(P<0.05)。③治疗组与对照组总有效率分别为90%、72%,组间比较差异有统计学意义(P<0.05)。④两组用药后关节红肿热痛时间:治疗组为3±1.2d,对照组为7±2.6d,治疗组明显短于对照组(P<0.01)结论:痛风膏治疗痛风有较好疗效,其止痛迅速,改善肾功能,降低血尿酸,减少蛋白尿。Objective： To study the therapeutic effect of gout ointment on gout treatment. Methods： One hundred cases of gout patients were divided into 2 groups. Patients in control group were treated with Tongfengding Capsule, 2 capsules each time and 3 times a day. Aside from administration of Tongfengding Capsule, patients in treatment group received external application of gout ointment additionally twice a day. Two weeks as one course and all patients received 2 successive courses of treatment. Changes of blood β2-microglohutin （β2-MG）, hemoglobin （Hh）, 24h urinary protein （24h UP）, blood uric acid （BUA） as well as kidney function were observed. Results：①After treatment, levels of β2-MG and 24h UP decreased significantly （P〈0.01） and Hb increased remarkably （P〈0.01） in treatment group, while there was no obvious changes in control group （P〉0.05）. ②BUA, BUN and Set were decreased in both groups, with a larger decrease in the treated group （P〈0.01）. ③The total effective rate was 90% in the treated group, which was significantly higher than 72% in the control group （P〈0.05）. ④In the course of treatment, patients in the treatment group had an average time of （3±1.2） days for joint pain, which was notably shorter than （7±2.6） days in control group （P〈0.01）. Conclusion：The gout ointment has a favorable therapeutic effect on gout and its mechanism could be related with improving renal function, lowering serum uric acid and reducing proteinuria.

关 键 词：痛风膏 痛风 中医药治疗 尿酸 肾功能 

分 类 号：R274.39[医药卫生—中医骨伤科学]