CD_(34)^+细胞Fas抗原表达与疾病相关性的研究进展  

Research Progress on the Relationship Between the Expression of Fas Antigen on CD_(34)^+ Cells and Diseases

作　　者：边静[1] 党双锁[2] 

机构地区：[1]海南省农垦总局医院放射科,海口570311 [2]西安交通大学医学院第二附属医院感染科,西安710004

出　　处：《医学综述》2009年第20期3041-3045,共5页Medical Recapitulate

基　　金：国家自然科学基金(30670961)

摘　　要：Fas抗原(又称为CD95或Apo-1)是一种肿瘤坏死因子受体,它可与配体或抗体交联后激发一种能够导致细胞凋亡的信号转导级联反应。在正常造血过程中,CD34+造血干细胞表面并不表达Fas抗原。大量国内外研究发现,当CD3+4细胞表面发生Fas抗原的异常表达时,则与许多造血和非造血疾病的发生、发展密切相关,本文就CD3+4细胞表面Fas抗原的表达与某些疾病相关性予以综述。Fas antigen,also called CD95 or Apo-1,is a tumor necrosis factor receptor（TNF-R）.Fas antigen,coupled with a ligand or antibody,can initiate a signal transduction cascade reaction that leads to apoptosis.During normal hematopoiesis,Fas antigen is not expressed on CD34^＋ cells,however,a large number of researches from domestic and abroad show that the abnormal expression of Fas antigen on CD34^＋ cells is related to a variety of haematopoietic and non-haematopoietic diseases.This paper reviewed the relationship between the expression of Fas antigen on CD34^＋ cells and diseases.

关 键 词：CD34+细胞 FAS抗原 凋亡 

分 类 号：R575.2[医药卫生—消化系统]