葛根素对缺氧缺血性脑损伤保护作用的研究进展  

Researching Development of the Protective Effects of Puerarin in Hypoxic Ischemic Brain Damage

作　　者：于文红[1] 初桂兰[2] 

机构地区：[1]天津医科大学第二医院新生儿科,天津300211 [2]天津医科大学总医院儿科,天津300070

出　　处：《医学综述》2009年第20期3163-3165,共3页Medical Recapitulate

摘　　要：新生儿缺氧缺血性脑损伤(HIBD)是新生儿死亡和婴幼儿神经系统功能障碍的主要原因,围生期HIBD仍然是神经保护治疗的主要对象。研究HIBD发病机制及相应的治疗措施一直是医学研究的热点。中药制剂在神经保护中的作用亦得到关注。葛根素是由豆科植物野葛的干燥葛根提取物制成,主要化学成分为4,7-二羟基-8-β-D葡萄糖异黄酮。近年来葛根素对HIBD的保护作用得到深入广泛的研究。现就此方面资料予以综述,以期能为葛根素在HIBD中神经保护作用的研究提供一定的参考。Neonatal hypoxic-ischemic brain damage（HIBD） is a major cause of their neurological disability and mortality.Its therapy requires to be improved by a better understanding of the discrete neurotoxic molecular mechanisms triggered by hypoxia-ischemia（HI）.Now many studies have focused on the neuroprotection effects of traditional Chinese medicine against HIBD.Pueraria lobata（Wild.） Ohwi has been used in traditional Chinese medicine for centuries.A primary component of the most functional extracts of Pueraria lobata is puerarin.Puerarin（Pur）,8 β-D—glucopyranosy 1-4-7-dihydroxyisoflavone,has positive effects on HIBD.This article makes a brief review on the neuroprotection of Puerarin against HIBD,which is looking forward to providing some references on studying and researching in the relative investigations.

关 键 词：缺氧缺血 脑 葛根素 缺血/再灌注损伤 细胞凋亡 

分 类 号：R722[医药卫生—儿科]