脉冲CO_2激光骨组织消融和电钻磨削的弹坑形态比较  

A Comparison of Crater Morphology on Bone Tissue Created by Pulsed CO_2 Laser and Electronic Drill

作　　者：郭健[1] 张先增[1] 詹振林[1] 谢树森[1] 

机构地区：[1]福建师范大学激光与光电子技术研究所福建省光子技术重点实验室医学光电科学与技术教育部重点实验室,福建福州350007

出　　处：《激光生物学报》2009年第4期458-463,共6页Acta Laser Biology Sinica

基　　金：国家自然科学基金(60578057;60878062);卫生部科学研究基金-福建省卫生教育联合攻关计划资助项目(WKJ2008-2-035);福建省自然科学基金(2008J0317)

摘　　要：激光消融技术在生物骨硬组织领域具有广泛的应用前景。选用脉冲CO2激光对离体牛胫骨组织进行消融,以电钻作为参照组,体视显微镜和扫描电子显微镜观察骨组织弹坑的形态学变化,光学相干层析成像(OCT)技术测量弹坑消融深度。比较结果表明:脉冲CO2激光辐照骨硬组织后产生的消融凹陷在几何形状和形态学方面与电钻的磨削效果相类似。此外,喷水速率为31 mL/m in时可减少热损伤,并提高消融效率。Laser ablation of bone tissue has a broad application prospect in medicine field. The bovine shank bone tissue was ablated with pulsed CO2 laser in vitro, electronic drill was used as a control group. Then the morphology of bone tissue was examined by using stereomicroscope and scanning electron microscope （SEM）. The crater depth was measured with optical coherence tomography （OCT）. The results showed that the crater after pulsed CO2 laser ablation can obtain the same outcome in geometrical form and morphology as electronic drill. Furthermore, the water spray of 31 mL/ rain in the process of laser ablation can reduce thermal damage and improve ablation efficiency.

关 键 词：激光消融 骨 脉冲CO2激光 

分 类 号：R318.51[医药卫生—生物医学工程]