在体光声成像检测损伤组织及体内异物  

In vivo Photoacoustic Imaging of Traumatic Tissues and Foreign Bodies

作　　者：杨思华[1] 邢达[1] 

机构地区：[1]华南师范大学生物光子学研究院激光生命科学研究所,暨激光生命科学教育部重点实验室,广东广州510631

出　　处：《激光生物学报》2009年第4期539-543,434,共6页Acta Laser Biology Sinica

基　　金：国家自然科学基金项目(30870676;30870658);教育部"长江学者与创新团队计划"创新团队项目(IRT0829);广东省自然科学基金项目(7117865)

摘　　要：利用旋转扫描光声成像采集系统对脑损伤动物进行在体成像检测研究。对由金属物刺伤的脑内组织损伤和出血现象进行高分辨成像;光声成像成功定位小鼠颅骨内针刺损伤的位置和清晰展现组织损伤引致的颅内瘀血;成功利用光声成像观测到外损伤金属异物在颅内的形态结构及位置信息,分析了光声成像对金属异物定位检测和组织损伤出血分布的检测可行性,为提出新型的脑外伤检测技术作应用基础的研究。In this study, photoacoustic imaging system was conducted to visualize traumatic lesions in the mouse brain cerebral cortex. The position and the shape of traumatic lesions accompanying with hemorrhage in the mouse cortical surface were accurately mapped. Foreign bodies of small metal objects inserted into the mouse brain were also detected with high resolution PAI. Experimental results demonstrated that photoacoustic technique holds the potential for clinical applications in brain trauma and low density foreign body detection.

关 键 词：光声成像 在体检测 脑损伤 体内异物 

分 类 号：Q225[生物学—细胞生物学]