基于3469例血管病变患者证候分布规律的脉络病变共性病机探讨  

Research on Common Pathogenesis of Vessel Diseases of 3469 Patients based on TCM Syndrome Distribution

作　　者：贾振华 高怀林 谷春华 袁国强 吴相春 魏聪 

机构地区：[1]河北以岭医药研究院络病研究室、河北省石家庄市天山大街238号,050035

出　　处：《中医杂志》2009年第10期920-924,共5页Journal of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(“973”计划)资助项目(2005CB523301)

摘　　要：目的探讨脉络病变共性病机。方法选择3 469例血管病变患者开展临床流行病学调查,以熵的复杂系统分划方法提取证候,计算构成比,建立结构方程模型研究证候间因果关系。结果3 469例患者分为8个共性证候,络气郁滞证占31.94%,络气虚滞证占58.58%,兼有络气郁滞和虚滞证者占9.48%;血瘀58.11%、痰浊(热)42.66%、郁热24.59%、阴虚29.14%、阳虚28.37%;络气郁滞、络气虚滞均能引起血瘀、痰浊,络气郁滞可引起郁热。结论络气郁滞与络气虚滞为脉络病变始动因素并贯穿全过程,痰、瘀、热既是病理产物又是继发性致病因素。Objective To study the common pathogenesis of the vessel diseases. Methods The epidemiological study was carried out on 3 469 patients with vascular diseases, the TCM syndromes were diagnosed by using the entropy-based complex system partition method, the syndrome constituent ratio was calculated, and the structural equation model was set up for studying the causality among the syndromes. Results There were 8 common syndromes in 3469 patients. Collateral-qi stagnation syndrome was 31.94%. Collateral-qi deficiency syndrome was 58.58%. Collateral-qi stagnation combined with collateral-qi deficiency syndrome was 9.48%. Blood stasis syndrome was 58. 11%. Phlegm turbidity （fire） syndrome was 42.66 %. Stagnation heat syndrome was 24.59 %. Yin deficiency syndrome was 29.14%. Yang deficiency syndrome was 28.37%. Both collateral-qi stagnation and collateral-qi deficiency could induce blood stasis and phlegm turbidity while collateral-qi stagnation could also cause stagnation heat. Conclusion Collateral-qi stagnation and collateral-qi deficiency were the initiating agent, which existing in the whole process of vessel disease. Blood stasis, phlegm and stagnation heat were the pathological products and secondary causative factors as well.

关 键 词：血管病变 证候 病机 临床流行病学调查 

分 类 号：R259[医药卫生—中西医结合]