肺结节病27例临床分析  

Clinical analysis of 27 patients with pulmonary sarcoidosis

作　　者：肖庆龄[1] 孙德彬[2] 洪群英[3] 

机构地区：[1]江苏省中西医结合医院呼吸科,南京210028 [2]浙江省丽水市中心医院呼吸科,323000 [3]复旦大学附属中山医院肺科,上海200032

出　　处：《临床肺科杂志》2009年第11期1451-1453,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的对27例肺结节病进行临床分析,为早期诊断和治疗提供思路。方法对27例病理证实为非特异性肉芽肿的肺结节病患者进行回顾性分析,仔细观察这些患者的临床特征表现、影像特征变化、以及血钙、、血管紧张素转化酶(SACE)等,并进行分析归纳。结果肺结节病患者临床表现多样,无特异性,有较典型的影像学表现,血某些生化指标升高,纵隔镜或支气管镜肺活检等检查能确诊。结论详细的病史与比较特征性影像,早期进行活检是确诊的依据,其他血钙、SACE等升高对诊断肺结节病有一定参考作用,糖皮质激素可以改善肺结节病患者的临床症状与影像表现。Objective To summarize clinical material and early diagnosis of pulmonary sarcoidosis of 27 patients. Methods A retrospective analysis of 27 cases of pulmonary sareoidosis identified by pathology was conducted. We reviewed the changes in clinical presentations, radiographic features and the level of serum calcium and serum angiotensin-converting-enzyme （SACE） activity, etc. Resuits Pulmonary sarcoidosis manifested clinically in a variety of forms. The presence of hilar adenopathy on chest radiography and change of some serum biochemical indicators might suggest the diagnosis of sarcoidosis. All cases were confirmed through mediastinoscopy-guided biopsy or transbronchial lung biopsie. Conclusion Inquiring carefully combining with radiographic features and biopsy specimens are the keys to early diagnosis of pulmonary sarcoidosis. Some biochemical indicators such as serum calcium and SACE activity have certain value in the diagnosis. Corticosteroid can improve clinical presenting and radiographic features of cases with pulmonary sarcoidosis.

关 键 词：肺结节病 活检 血管紧张素转化酶(ACE) 

分 类 号：R563.9[医药卫生—呼吸系统]