非水电位滴定法测定盐酸莫雷西嗪原料的含量  

Study on Determination Method of Raw Material of Moricizine Hydrochloride

作　　者：曹凤习[1] 王淑惠 

机构地区：[1]河北省药品检验所,河北石家庄050011 [2]河北省石家庄市疾病控制中心,河北石家庄050017

出　　处：《中国药业》2009年第20期21-22,共2页China Pharmaceuticals

摘　　要：目的建立革除汞盐的非水电位滴定法测定盐酸莫雷西嗪原料的含量。方法建立以冰醋酸与醋酐(1:3)为溶剂的高氯酸非水电位滴定法测定盐酸莫雷西嗪原料的含量。结果与2005年版《中国药典(二部)》方法测定结果一致。结论该法操作简单,灵敏度高,准确可靠,重复性及稳定性良好,适于盐酸莫雷西嗪原料的含量测定。Objective To establish a method for the determination of the content of moricizine hydrochloride by non-aqueous potentiometric titration abolishing mercurate. Methods Using the method of non- aqueous potentiomctric titration of perchloric acid, in which glacial acetic acid and acetic anhydride （1：3） as solvent, to determine the content of moricizine hydrochloride. Results The results is the same as that of the determination method in Volume lI of the Chinese Pharmacopoeia（edition 2005）. Conclusion The method is simple, sensitive and accurate with good repeatability and stability, which can be applied to the determination of moricizine hydrochloride.

关 键 词：盐酸莫雷西嗪 原料 含量 测定 非水电位滴定法 

分 类 号：R927.2[医药卫生—药学] R972.2