合并HHV-6和/或HCMV感染的器官移植病人IFN-a和TNF-a水平的研究  

THE STUDY ON THE INTERFERON-a AND TUMOR NECROSIS FACTOR-a IN ORGAN TRANSPLANT RECIPIENTS COMPLICATED WITH HHV-6 AND/OR HCMV INFECTION

作　　者：罗敏华[1] 邬国军[1] 肖杨名[1] 陈欲晓[1] 毛学政[1] 陈淑珍[1] 齐范[1] 鲁尔雄[1] 

机构地区：[1]湖南医科大学微生物学教研室

出　　处：《实用预防医学》1998年第6期328-330,共3页Practical Preventive Medicine

基　　金：湖南省中药局资助;湖南省卫生厅重点资助

摘　　要：为探讨病毒感染时ＩＦＮ—ａ与ＴＮＦ—ａ水平及其致病作用，及其与排斥反应的关系，用ＥＬＩＳＡ双抗夹心法检测器官移植病人血清中ＩＦＮ—ａ与ＴＮＦ—ａ水平。结果发现病毒ＨＣＭＶ和／或ＨＨＶ—６感染组血清中ＩＦＮ—ａ与ＴＮＦ—ａ含量明显高于对照组，且呈正相关；感染组在免疫排斥时血清中ＩＦＮ—ａ与ＴＮＦ—ａ含量明显高于非排斥时。表明免疫抑制的器官移植病人ＩＦＮ—ａ在抗病毒感染中起作用，ＩＦＮ—ａ与ＴＮＦ—ａ参与病毒感染的炎症过程，并参与了免疫排斥反应。In order to probe the level and pathogenicity of the Interferon-a(IFN-a) and tumor necrosis factor-a(TNF-a),as well as the relationship with the rejection reaction,the IFN-a and TNF-a in sera of organ transplant recipients were detected by enzyme linked immunosorbent assay(ELISA). The results showed that the levels of IFN-a and TNF-a in the group complicated with human herpesvirus 6(HHV-6) and/or human cytomegalovirus(HCMV)infection were obviously higher than that of noninfected group(P<0 01), and the level of IFN-a correlated positively with that of TNF-a during the period of HHV-6 and/or HCMV infection(r=0.8019). In the group complicated with HHV-6 and/or HCMV infection, levels of IFN-a and TNF-a were obviously higher at immunorejection than without immunorejction(P<0 05). The results indicate that IFN-a and TNF-a may play a role in antivirus infection, may involve in inflammation and damage caused by virus infection, and may involve in immunorejection.

关 键 词：IFN-α INF-Α 病毒感染 免疫排斥 器官移植 

分 类 号：R392.4[医药卫生—免疫学]