应用MATLAB求算静脉注射给药的药动学参数  

Calculation of Pharmacokinetic Parameters by Intravenous Injection Based on MATLAB

作　　者：杨帆[1] 

机构地区：[1]华南农业大学兽医学院,广东广州510642

出　　处：《抗感染药学》2009年第3期157-161,共5页Anti-infection Pharmacy

摘　　要：目的:应用MATLAB求算静脉注射给药的药动学参数。方法:利用MATLAB的inline和nlinfit命令进行非线性拟合,求解药动学参数。结果:MATLAB可方便快速求解静脉注射给药途径下的各个药动学参数,结果与3P97计算结果相当。结论:本方法操作简便、界面直观、结果可靠、易于推广,可用于临床教学或实验中药动学参数的计算。Objective： To calculate pharmacokinetic parameters by intravenous injection based on MATLAB. Methods：To calculate pharmacokinetic parameters mainly using the commands of ＂inline＂ and ＂linfit＂ . Results： MATLAB can be used to directly calculate the pharmacokinetic parameters, with calculation results in line with those calculated based on 3P97. Conclusion： The established method is simple, direct-viewing, reliable and easy to be operated and popularized, and it can be used to calculate pharmacokinetic parameters in clinical teaching or experiments.

关 键 词：非线性回归 拟合 MATLAB 静脉注射 药动学参数 

分 类 号：R969.1[医药卫生—药理学]