双对照考察甲硝唑二磷酸钠与头孢匹胺钠配伍  

Stability Studies on Metronidazole Disodium Phosphate & Cefpiramide Sodium Mixed with Sodium Chloride Injection

作　　者：谭蓉[1] 胡晓波[1] 饶丹[1] 

机构地区：[1]贵阳医学院附属医院,贵州贵阳550004

出　　处：《抗感染药学》2009年第3期185-188,共4页Anti-infection Pharmacy

摘　　要：目的:考察注射用甲硝唑磷酸二钠与头孢匹胺钠配伍的稳定性。方法:甲硝唑磷酸二钠与头孢匹胺钠(0.915∶1)同溶于9.0mg/mL氯化钠注射液中制得待测溶液,并按相同条件制得含甲硝唑磷酸二钠及头孢匹胺钠的对照溶液,20℃密闭放置0～4h,分别对其溶液外观、pH值和紫外吸收光谱检查。在波长273,320,367nm处用紫外分光光计分别测定甲硝唑磷酸二钠与头孢匹胺的质量浓度,将所得结果进行统计学分析。结果:在0,0.5,1.0,2.0,3.0,4h溶液外观、pH值和紫外吸收光谱基本不变化,甲硝唑磷酸二钠与头孢匹胺钠回收率分别为99.72%,99.47%,100.06%,99.35%,100.21%,99.84%和100.13%,99.18%,100.19%,99.98%,99.41%,99.09%,对照溶液中所含甲硝唑磷酸二钠及头孢匹胺钠回收率值与配伍溶液中所含二药回收率值相比较,无显著性差异(P<0.05)。结论:注射用甲硝唑磷酸二钠与注射用头孢匹胺钠于9.0mg/mL氯化钠注射液中在实验考察的范围内可配伍。Objective： To investigate the stability of metronidazole disodium phosphate for injection combined with cefpiramide sodium for injection studied. Methods： The test solution was prepared by metronidazole disodium phosphate and cefpiramide sodium（0.915：1） dissolved in 0.9% sodium chloride injection. The blank control solution of MDP and CPA was prepared with the same. The sample was allowed to stand 0-4h at 20 ℃. The appearance of the solution is observed, pH value and UV absorbance spectrum of samples was measured, the amount of MDP and CPA was measured by UV spectrometer at 273, 320 and 367 nm and the results were analyzed by statistical analysis. Results： The appearance of the solution, pH value and UV absorption spectrum were changed in 0-4 h; The recovery rate of MDP and CPA in combined solustion at 0.0, 0.5, 1.0, 2.0, 3.0, 4.0 h were 99.72%, 99.47%, 100.06%, 99.35%, 100.21%, 99.84% and 100.13%, 99.18%, 100.19%, 99.98%, 99.41%, 99.09%, Respectively. The recovery rate, comparison with the results of control solution had no significant difference by statistical analysis（p 〈 0.05）. Conclusion： Metronidazole disodium phosphate for injection mixed with cefpiramide sodium for injection can be combined in 0.9% sodium chloride injection.

关 键 词：双空白对照 头孢匹胺钠 甲硝唑磷酸二钠 配伍 

分 类 号：R927.11[医药卫生—药学]