中药防治氨基糖苷类药物耳毒性的研究进展  

Research Advances in Prevention & Cure of Ototoxicity Caused by Aminoglycoside Antibiotics Using Traditional Chinese Medicines

作　　者：黄倩[1] 赵长振[1] 曹碧茵[2] 

机构地区：[1]苏州大学 [2]苏州大学附属第二医院,江苏苏州2150042

出　　处：《抗感染药学》2009年第3期218-222,共5页Anti-infection Pharmacy

摘　　要：该文介绍了氨基糖苷类抗生素耳毒性的发生机制,回顾了中药对氨基糖苷类抗生素耳毒性防治作用的研究资料,总结并分析了10味中药(川芎、丹参、刺五加、当归、黄芩、葛根、茯苓、骨碎补、儿茶素、月见草)和多种复方制剂(复聪片、耳聋左慈丸、金匮肾气丸、天鼓冲剂、复方丹参、补肾聪耳片等)对氨基糖苷类抗生素实验性耳毒性的防治作用及可能机制。To Introduce the mechanism of ototoxicity caused by aminoglycoside antibiotics. To review the data about effectiveness of Traditional Chinese Medicines in treating ototoxicity of aminoglycoside antibiotics. Were Summarized and analyzed 10 kinds of herb（Ligusticum chuanxiong Hort., Radix Salviae Miltiorrhizae, Eleu-therococcus senticosus （Ruper.et Maxim.）, Radix Angelica, Radix Scutellariae,Pueraria lobata（Willd.）, Poria cocos（Schw.） Wolf, Rhizoma Drynariae, catechin, Oenothera erythrosepala Borb.） and a variety of compound （Fucong tablet, Erlong zuoci pill, Jinkui Shenqi Pill, Tiangu Granule, Fufang Danshen tablet, Bushen Cong-er tablet, etc.）, Their effectiveness on treating experimental ototoxicity of aminoglycosides antibiotics as well as their possible mechanisms.

关 键 词：中药 氨基糖苷类 耳毒性 

分 类 号：R931.71[医药卫生—生药学] R978.12[医药卫生—药学]