金牛煎对大鼠及家兔癌性发热的影响及其抑瘤作用的实验研究  

LABORATORY STUDY ON THE EFFECT OF JINNIUJIAN ON RAT'S AND RABBIT'S CANCEROUS FEBRILE AND ITS INHIBITION EFFECT ON CANCER

作　　者：许继平[1] 应栩华[1] 李端阳[1] 杨加珞 

机构地区：[1]浙江省中医药研究院,杭州310007

出　　处：《中国中医药科技》1998年第6期342-344,共3页Chinese Journal of Traditional Medical Science and Technology

摘　　要：在金牛煎临床治疗癌性发热取得较好疗效的基础上,为了进一步证实其效果及探讨其作用机理,采用S_180肉瘤细胞悬液煮沸法制作癌性发热动物模型,观察金牛煎对其作用及其抑瘤作用和对荷瘤小鼠免疫功能的影响。结果表明S_180细胞悬液煮沸法造模灵敏度高,时间长,重现性好。金牛煎3剂量组对癌性发热家兔及大鼠有明显抑制发热作用,其作用明显优于对照组(P<0.05～0.01),且其降温作用稳定,无反复现象,优于地塞米松。金牛煎3剂量组对S_180、Lewis肺癌、肝癌实体瘤荷瘤小鼠均有明显抑瘤作用,并可延长艾氏腹水瘤小鼠的生存期,提高生存率,对荷瘤小鼠NK细胞活性及T、B淋巴细胞转化功能均有明显促进作用。由此提示金牛煎抗癌性发热疗效是确切的,其作用机制可能是通过抑制肿瘤细胞而起作用的,且无明显的免疫抑制作用。In order to confirm the effect of Jinniujian on cancerous febrile and approach its mechanism, animal experiment was taken on the decoction on rat and rabbit with cancerous febrile modelled by injected SISQ cell suspension and immunologic function of mice with cancer. The results showed that the three dosage groups with Jinniujian could significanthy inhibit the febrile of rat s and rabbit' s cancerous febrile, the effect was obvious better than that of control group (P<0.05-0.01). and the hypothermy function was stabilization, was better than that ot western medicine. Jinniujian could significantly inhibit on mice with solid cancer,could obviously prolong the survival time of mice with hydroperitoneum carcinoma, raise the survival rate, the decoction could significantly promote the activity of NK cell and transformatfion function of T and B lymphocyte of mice with cancer. All these suggested that the effect Jinninjian on cancerous febrile was definite, its mechanism maybe inliibit the tumor cell, and there was no side effect on immunological system.

关 键 词：发热 金牛煎 癌 中医药疗法 自然杀伤细胞 

分 类 号：R273[医药卫生—中西医结合]