异位宁对实验性大鼠子宫内膜异位症IL-6 mRNA影响的实验研究  

Experimental Research of Yiweining on Impact of IL-6 mRNA in Experimental Rats with Endometriosis

作　　者：王艳萍[1] 马文光[2] 马宝璋[2] 

机构地区：[1]长春中医药大学附属医院,吉林长春130021 [2]黑龙江中医药大学附属一院,黑龙江哈尔滨150400

出　　处：《世界中西医结合杂志》2009年第9期621-623,共3页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的探讨异位宁对实验性大鼠子宫内膜异位症白细胞介素-6 mRNA(IL-6 mR-NA)的影响。方法以原位杂交法测定各组大鼠的IL-6 mRNA的表达水平。结果子宫内膜异位症大鼠异位内膜组织中IL-6 mRNA的表达较正常对照组增强。异位宁高剂量组异位内膜IL-6 mRNA的阳性表达与模型组相比有显著性差异(P<0.01)。结论异位宁对异位内膜IL-6 mRNA阳性表达有降调作用,该研究为探讨异位宁在子宫内膜异位症领域的临床应用提供了理论依据和实验基础。Objective To explore the impact of Yiweining on interleukin -6mRNA（IL -6 mRNA） in experimental rats with endometriosis（EM）. Methods In situ hybridization was used to detect the level of tL - 6 mRNA of rats in ever）, group. Results The expression of IL - 6 mRNA was higher in EM group than that in normal group. The positive expression of EMIL - 6 mRNA in Yiweining of high dose group presented significant difference compared with model control group（ P 〈 0.01 ）. Conclusion The experiment indicates that Yinweining down- regulates the positive expression of EMIL- 6 mRNA,which provides a theoretic evidence and experimental basis on the clinical application of Yinweining in treatment of endometriosis.

关 键 词：子宫内膜异位症 异位宁 白细胞介素-6 MRNA 

分 类 号：R711.71[医药卫生—妇产科学] R-332[医药卫生—临床医学]