慢性阻塞性肺疾病炎症反应研究进展  

Research advancement on inflammatory response of chronic obstructive pulmonary disease

作　　者：张海龙[1] 曹帆[1] 李建生[1] 余学庆[1] 

机构地区：[1]河南中医学院老年医学研究所,郑州450008

出　　处：《国际呼吸杂志》2009年第19期1191-1195,共5页International Journal of Respiration

基　　金：国家科技支撑计划课题（2006BAI0413-2）;国家自然科学基金资助课题（30772797）

摘　　要：目前研究显示气道炎症是慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）发病过程中的一个关键环节，中性粒细胞、淋巴细胞和肺泡巨噬细胞等多种炎症细胞和白三烯B4、白介素8、肿瘤坏死因子α、白介素6、基底细胞间黏附分子等多种炎症介质参与并影响气道炎症的发生。认识COPD炎症反应的特点和影响因素，能对COPD发生机制的探讨和临床治疗产生深远的影响。At present,studies have shown that airway inflammation is a key element in the invasion process of chronic obstructive pulmonary disease（COPD）, various inflammatory cells such as neutrophils, lymphocytes and alveolar macrophages and kinds of inflammatory mediators such as leukotriene B4, interleukin-8, tumor necrosis factor-a, interleukin-6, intercellular adhesion molecular-1 participate and influence the occurrence of airway inflammation. Understanding the characteristics and impact factors of inflammatory response in COPD can bring about a far-reaching impact for the mechanism of the occurrence and the clinical treatment of COPD.

关 键 词：慢性阻塞性肺疾病 炎症反应 炎症细胞 炎症介质 

分 类 号：R563.9[医药卫生—呼吸系统]