血吸虫病免疫应答及其调节  

Immune responses and its regulation in schistosomiasis

作　　者：刘述先[1] 

机构地区：[1]中国疾病预防控制中心寄生虫病预防控制所、世界卫生组织疟疾、血吸虫病和丝虫病合作中心、卫生部寄生虫病原与媒介生物学重点实验室,上海200025

出　　处：《国际医学寄生虫病杂志》2009年第5期279-285,共7页International JOurnal of Medical Parasitic Diseases

摘　　要：该文以血吸虫生活史不同发育阶段（尾蚴、虫卵、成虫）诱导的免疫应答以及血吸虫病临床各期（急性期和慢性期）的免疫应答为主，综述近年来血吸虫病免疫应答的研究进展。在血吸虫病免疫应答的调节方面内容较多，限于篇幅，该文主要从细胞因子的调节作用，参与免疫应答调节的淋巴细胞及其亚类（或表型），尾蚴（或童虫）排泄分泌抗原（0-3hRP等）中某些具免疫调节作用的分子等3方面加以综述。Recent advances in research on the immune responses of schistosomiasis were reviewed in two aspects including the immune responses induced by different development stages （such as cercariae, eggs, adult worms） in the life cycle of schistosome, as well as the immune responses related to different clinical phases in schistosomiasis （acute or chronic phases）. As for the regulation of immune responses in the host infected with schistosomiasis, a lot of progress has been made mainly in the areas such as the cytokines related to regulation of immune responses during acute and chronic schistosomiasis, the lymphocytes and its subsets （ or phenotypes） involved in immune regulations, and the regulatory molecules or proteins from cercarial or schistossomula excretion and secretion（ES） antigen preparations, or in vitro cercarial 0-3 h release products （0-3hRP）etc. in schistosomiasis.

关 键 词：血吸虫病 Th1和Th2型免疫应答 细胞因子 免疫调节 固有免疫应答 排泄分泌物抗原 基因双缺失小鼠 

分 类 号：R285.5[医药卫生—中药学] R512.62[医药卫生—中医学]