产生过氧化氢的乳酸杆菌对淋球菌生长的影响  

Effect of H 2O 2 producing lactobacilli on neisseria gonorrhea growth.

作　　者：郑和义[1] 曹经江[1] 何志新[1] 王家璧[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院皮肤性病科

出　　处：《中国皮肤性病学杂志》1998年第6期330-332,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的：为了研究乳酸杆菌对淋球菌生长的影响。方法：将产生和不产生过氧化氢的乳酸杆菌（ＬＢ＋和ＬＢ－）与过氧化氢酶阳性和阴性淋球菌菌株置于适合两种细菌生长的混合培养液在体外混合培养。结果：在混合培养液ｐＨ值维持在７．３时，ＬＢ＋和ＬＢ－几乎对淋球菌的生长无影响，但当混合培养液ｐＨ值５．０时，ＬＢ＋和ＬＢ－均能抑制淋球菌的生长，ＬＢ＋比ＬＢ－的抑制作用更显著，而且对过氧化氢酶阴性比阳性淋球菌的抑制作用更明显。结论：认为ＬＢ＋能通过酸化环境和产生Ｈ２Ｏ２而抑制淋球菌的生长。Objective:Inorder to study the effect of lactobacilli on neisseria gonorrhea growth.Method:H 2O 2 producing(LB+)and non producing(LB ) lactobacilli were coincubated with catalase positive and negative strains of N.gonorrhea at the medium which supported the viability of both organisms in vitro.Result When the incubation medium was maintained at pH 7.3,either LB+nor LB affected gonococal growth.When coincubation medium was at pH 5.0,both LB+and LB effectively inhibited gonoccal growth.The inhibition of LB+ was significantly stronger than that of LB .Inhibition of gonococal growth of catalase negative was significantly stronger than that of catalase positive strain by LB+.Conclusion:LB+ may inhibit the growth of gonococci by acidofication of the environment and secretion of H 2O 2.

关 键 词：乳酸杆菌 奈瑟氏球菌 淋病 过氧化氢 

分 类 号：R759.202[医药卫生—皮肤病学与性病学] R378.16[医药卫生—临床医学]