TNF和bFGF对室旁核神经元树突结构发育的影响  

EFFECTS OF TNF AND bFGF ON DEVELOPMENT OF DENDRITE OF PERIVENTRICULAR NUCLEUS

作　　者：窦寰宇[1] 蒋吉英[1] 高培福[1] 曹焕军[1] 鞠晓华[1] 刘向平[1] 

机构地区：[1]潍坊医学院解剖学教研室

出　　处：《潍坊医学院学报》1998年第4期241-243,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨肿瘤坏死因子（ＴＮＦ）和碱性纤维细胞生长因子（ｂＦＧＦ）对室旁核神经元形态发育的影响。方法给出生后小鼠颅内直接注射ＴＮＦ和ｂＦＧＦ，至１周和１月龄，行Ｇｏｌｇｉ－Ｋｏｐｅｈ方法显示神经元树突结构。用ＮＴＳ和Ｓｈｏｌ分析树突野范围和树突总长度。结果ｂＦＧＦ和ＴＮＦ低浓度组树野分布均匀，分枝多；树突总长度与对照组和ＴＮＦ高浓度组相比有显著差异。结论ｂＦＧＦ和ＴＮＦ是神经发育的诱向性因素之一。Objective In order to explore the effect of TNF and bFGF on the development of periventricular neucleus nurons.Method By Golgi Kopeh method the dendrite of neurons was showed;Using the NTS and Sholl method the dendritic arbors were analysed.Result As compared with control and high does TNF groups,the dendritic branches of periventricular nucleus neurons were more,the dendritic distribution was more extensive;and there was significant difference in the total dendrite length in low does TNF and bFGF groups.Conclusion TNF and bFGF were one of the guidance factors for development of periventricular neucleus cells.

关 键 词：肿瘤坏死因子 BFGF 室旁核 树突结构 发育 

分 类 号：R338[医药卫生—人体生理学]