肝内胆汁淤积症患者血清甘胆酸水平与母儿预后的关系  

Study on relationship between serum cholylglycine and prognosis of mother and fetus in patients with intrahepatic cholestasis of pregnancy

作　　者：马丽萍 王月华 李红侠[2] 钱延玲[2] 

机构地区：[1]陕西洛川县人民医院,延安陕西727400 [2]延安大学附属医院,延安陕西716000

出　　处：《海南医学院学报》2009年第10期1291-1293,共3页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(0020090210)~~

摘　　要：目的:探讨妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)患者血清甘胆酸(serum cholyglycine,SCG)水平与母儿预后的关系。方法:比较妊娠期肝内胆汁淤积症患者90例(ICP组)与正常孕妇110例(对照组)的母儿状况,应用放免法测定SCG(μg/dL)值,记录分娩方式、胎儿窘迫、Apgar评分等新生儿预后及产妇产后出血情况。结果:随着SCG水平升高,新生儿窒息发生率,胎儿窘迫发生率,剖宫产率及产后出血发生率均明显升高。结论:SCG水平是预测ICP孕妇产后出血、胎儿宫内情况及其预后的一个重要量化数据,对胎儿出生后早期康复干预有参考价值。Objective：To investigate the relationship between serum cholylglycine and prognosis of mother and fetus in patients with intrahepatic cholestasis of pregnancy.Methods： 90 intrahepatic cholestasis of Pregnancy（ICP） cases were compared with 110 healthy pregnant women.SCG levels of all cases were determined by radioimmunoassay;mode of delivery,occurrence of fetal distress,postnatal Apgar scores and postpartum hemorrhage were recorded and compared.Results： Rate of cesarean section and incidence of fetal distress,neonatal asphyxia,and postpartum hemorrhage all increased significantly with SCG level.Conclusion： SCG level is a quantitative predictor of mother and fetus health condition in ICP cases and can be used for reference in early rehabilitation and intervention of new borne infants.

关 键 词：妊娠期 肝内胆汁淤积症 甘胆酸 母儿预后 

分 类 号：R714.25[医药卫生—妇产科学]