大剂量糖适平治疗Ⅱ型糖尿病病人75例量效关系的分析  

A dosage efficacy analysis of large dose of glurenorm in the treatment of 75 cases with type Ⅱ diabetes

作　　者：邓尚平[1] 池芝盛[2] 李秀钧[1] 冯登尧 许樟荣 刘颖耿 张喆[6] 金星 李美莲[8] 刘永志 冯颖[10] 刘雪萍 于国宁[12] 

机构地区：[1]华西医科大学,610041 [2]北京协和医院 [3]仁寿人民医院 [4]北京514医院 [5]沂州人民医院 [6]天津公安医院 [7]北京铁路总医院 [8]北京酒仙桥医院 [9]衡阳医学院 [10]鞍钢铁西医院 [11]本溪钢铁职工医院 [12]天津第一中心医院

出　　处：《中国糖尿病杂志》1998年第4期212-215,共4页Chinese Journal of Diabetes

摘　　要：对单用大剂量糖适平（>120mg／d）治疗Ⅱ型糖尿病患者75例的结果作了分析。试验时间5～7个月，每2周测一次空腹及餐后2小时血糖。血糖达到控制的标准订为：空腹≤7．8mmol／L及餐后2小时≤11．lmmol／L。结果：分4种情况，①42例开始时用常规剂量（15～120mg／d），因血糖控制不满意，逐渐加大剂量。血糖逐渐下降达到控制标准，其中最终所用糖适平剂量为＞135mg／d（n=3）、＞150mg／d（n=5）、＞180mg／d（n=22）及210～275mg／d（n=12）；②12例病人因血糖甚高，从开始或两周内，即用180mg/d并持续到试验末。空腹及餐后血糖在2个月内逐渐下降达标；③8例用药情况与①相似，最终剂量平均达190～230mg／d，但试验末只有餐后血糖达标（10．2土0．8mmol／L），空腹血糖未达标；④13例用药情况同①，最终剂量达270mg／d，试验7个月空腹及餐后血糖仍未达标。本组结果说明，在对糖适平一般剂量反应差的糖尿病病人中，有80％以上的病人加大药物剂量可能增加效果，使血糖得到较好的控制，并无更多的低血糖发生。75 type Ⅱ diabetics were treated with large dose(>120mg/d)of glurenorm in a clinical trial for 5~7 months. FBG and 2h PBG were tested every 2 weeks. The criteria for acceptable blood glucosecontrol were FBG≤7. 8mmol/L and 2h PBG≤11. lmmol/L. The results were set into 4 groups:①42 casesused usual dosage (15~ 120mg/d) of glurenorm at the beginning and then gradually increased the dosagebecause of poor response to the drug. When large doses of glurenorm were used (> 135~ 150mg/d, n= 3;>150~ 180mg/d, n= 5; >180mg/d, n= 22 and 210~ 270mg/d, n=12). Both FBG and PBG decreasedand reached the criteria of blood glucose control.②12 patients used large dose of glurenorm (180mg/d)fromthe beginning or within the first two weeks of the trial because of very high blood glucose. Their FBG andPBG decreaed gradually within two months and maintained to the end of the trial.③8 patients had gradually increased their doses of glurenorm to a mean of 190~ 230mg/d. Their PBG had finally reached the control criteria but not the FBG.④13 patients had never been controlled during the trial either for FBG orPBG even they had increased the glurenorm dosage to 270mg/d. The results showed that more than 80%of type Ⅱ diabetics with poor blood glucose control using conventional dosage of glurenorm could unequivocally be improved with much larger dose of the drug and without more hypoglycemic side effects.

关 键 词：糖尿病 糖适平 治疗 

分 类 号：R587.105[医药卫生—内分泌]