卡托普利对大鼠系膜细胞钙离子的影响  

Effect of captopril on Ca^（2+）of rat glomerular mesangial cells

作　　者：王立[1] 潘长玉[2] 

机构地区：[1]首都医科大学宣武医院内分泌科 [2]中国人民解放军总医院内分泌科,100853

出　　处：《中国糖尿病杂志》1998年第4期224-226,共3页Chinese Journal of Diabetes

摘　　要：通过体外培养肾小球系膜细胞的方法，采用激光共聚焦显微镜技术，测定细胞内游离Ca2+水平。结果发现卡托普利对肾脏系膜细胞钙有直接抑制作用，其引起的细胞内Ca2+荧光强度下降反应曲线与药物浓度有一定关系。血管紧张素转换酶抑制剂对细胞内Ca2+的这种抑制作用可能是这类药物对肾脏保护作用的众多机制之一。To study the effect of captopril on renal protection,the intracellular Ca2+ level of rat mesangial cells cultured in vitro was detected with laser scanning confocal microscopy. The results showed thatcaptopril directly decreases the Ca2+concentration of glomerular mesangial cells,which demonstrated a closecorrelation between curves for inhibitive effect of captopril on the fluorescence signals of cytoplasmic Ca2+and concentration of captopril. This finding might be an important contribution to the mechanism of the renal protective effect of ACEI.

关 键 词：系膜细胞 卡托普利 ACEI 

分 类 号：R972.4[医药卫生—药品] R965.2[医药卫生—药学]