阿霉素磁性毫微球的体内外释放研究  

Drug release of doxorubicin-loaded magnetic microsphere in vitro and in vivo

作　　者：吕凤娇[1] 许小平[2] 

机构地区：[1]泉州师范学院化学与生命科学学院,泉州362000 [2]福州大学化学化工学院,福州350002

出　　处：《海峡药学》2009年第9期12-14,共3页Strait Pharmaceutical Journal

基　　金：福建省教育厅A类科技项目(JA08213);福建省自然科学基金。编号:2008J0100;泉州师范学院2008年度校自选项目(2008KJ08)

摘　　要：本文以阿霉素为模型药物,Fe3O4为磁核材料,单体乙烯吡咯烷酮为基质,通过反相乳液聚合方法制备了阿霉素磁性毫微粒,对其体内外释放性进行研究。结果发现,在体外释放研究中,毫微粒存在突释现象,72h时达到平衡,缓释效果较好;在给定同样剂量条件下,阿霉素溶液刚开始时获得较高血药浓度,但血药浓度又很快降低,在12h时血药浓度已经很低,而载药毫微粒在体内的消除较慢,在24h依然保持一定浓度,表现出一定的缓释性。Doxorubicin-loaded magnetic microparticles, using doxorubicin as model drug, Fe3O4 as core and vinylpyrrolidone as matix material, were prepared by inverse emulsion polymerization in this paper, and the drug release kinetics in vitro and in vivo were also measured. HPLC-FLD was utilized for the determination of ADM contention in blood plasma. The consequence indicated that release of microsphere was much better than ADM solution; The ADM solution obtained the tiptop ADM concentration in plasma at 0.15h, but reduced obviously and ADM concentration in plasma was little at 12h. To the NP, ADM concentration in plasma was still detected at 24h.

关 键 词：阿霉素 磁性微球 高效液相色谱 释放 

分 类 号：R927.2[医药卫生—药学]