江西省2004～2007年脊髓灰质炎疫苗相关株AFP病例分析  

AN ANALYSIS OF AFP CASES ON VACCTINE ASSOCIATED PARAYTIC POLIOMYLITES IN JIANGXI PROVINCE IN 2004-2007

作　　者：刘丽萍[1] 张洪荣[1] 方晓艳[1] 龚甜[1] 曾艳文[1] 

机构地区：[1]江西省疾病预防控制中心,南昌330029

出　　处：《现代预防医学》2009年第18期3565-3566,3569,共3页Modern Preventive Medicine

摘　　要：[目的]了解江西省AFP病例监测脊灰疫苗相关株的状况,分析江西省近年人群中脊灰病毒变化趋势。[方法]对江西省2004～2007年分离出脊灰疫苗相关株的AFP病例进行流行病学和病原学分析。[结果](1)Ⅲ型分离率和构成比从2006年开始显著上升,而且,Ⅲ型发生变异最多,变异核甘酸数也最多。(2)疫苗相关株的58例AFP病例中未免疫或未全程免疫的儿童占51.7%。(3)脊灰病毒分离率与采集标本时的服苗时间有关。[结论]对脊灰病毒在人群中的变化趋势进行分析,可以预测VDPVs的发生和流行,可为提前采取防控措施提供依据。消灭脊灰进程中,尽早实现使用脊灰灭活疫苗、直至停止使用脊灰疫苗很有必要。[Objective] To know the status of AFP csses on vaccine related Polioviruses strain in JiangXi province, and to analyze the poliovirus change tendency of JiangXi crowd in recent years. [ Motheds] AFP cases on vaccine related Polioviruses strain in JiangXi province in 2004-2007 were analzed by epidemiological and aetiological analysis. [Results] （1） The isolating rate and the constituent ratio of type Ⅲ polioviruses began obviously rising from 2006, and, the variation and the number of nucleotide variation were at most. （2） The not and not fully vaccinated children is 51.7% from 58 acute flaccid paralysis （AFP） cases. （3） The isolating rate of the polioviruses was related with the take vaccine time of the sample collection. [Conclusion] By analyzing the crowd’ s poliovirus change tendency, we can predict the occurrence and prevalence of VDPVs, and provid the evidence for taking some Control and Prevention measures in advance. During the eliminating polioviruses process, it is necessary to perform inactivated vaccine to no vaccine earlily.

关 键 词：急性迟缓性麻痹(AFP) 脊髓灰质炎疫苗相关株(脊灰疫苗相关株) 疫苗衍生株脊髓灰质炎病毒循环(cVDPVs) 

分 类 号：R373.22[医药卫生—病原生物学]