盐酸水苏碱在中药生产过程中的含量变化及影响因素研究  

Study on Content Change of Stachydrine Hydrochloride in Chinese Medicine Production Process

作　　者：黄鸣清[1] 陈瑞云[1] 谢友良[1] 蒋东旭[1] 张怡评[2] 江滨[1] 赖小平[1] 

机构地区：[1]广州中医药大学,广东广州510405 [2]国家海洋局第三海洋研究所,福建厦门361009

出　　处：《时珍国医国药》2009年第10期2587-2589,共3页Lishizhen Medicine and Materia Medica Research

摘　　要：目的探讨盐酸水苏碱在中药生产过程中的含量变化及影响因素。方法建立盐酸水苏碱HPLC含量测定方法,考察提取、浓缩、干燥工艺中各影响因素对盐酸水苏碱保留率的影响,分析益母草药材储藏过程中的各主要影响因素。结果水提取工艺中提取时间、提取温度、提取次数、水用量对盐酸水苏碱的影响较小;浓缩过程中盐酸水苏碱有一定损失,但浓缩温度、浓缩时间、真空度并非主要影响因素;干燥过程中的温度、真空度、时间等参数对盐酸水苏碱的影响较小。在益母草储藏过程中,见光降解是盐酸水苏碱含量下降的主要原因。结论光对盐酸水苏碱的稳定性有重大影响。Objective To explore the content change of stachydrine hydrochloride in Chinese medicine production process. Methods An HPLC method was established stachydrine hydrochloride to determine the content of retention rate of stachydrine hydrochloride was applied as the parameters to investigate the processes of extraction, concentration and drying and the main factors in the storage of herba leonuri was investigated by factorial analysis. Results The influence of time, temperature, frequency, and water volume in extraction process to stachydrine hydrocbloride was weak. There is a little loss of stachydrine hydrochloride in concentration process ; the influence of temperature, time, and vacuum value to stachydrinc hydrochloridc was weak. Decompose by light was the most important factor to content decline of stachydrine hydrochloride in the storage of herba leonuri. Conclusion - Light showed a marked influence on the stability of stachydrine hydroehloride.

关 键 词：盐酸水苏碱 益母草 高效液相色谱 见光降解 

分 类 号：R283[医药卫生—中药学]