鲍曼不动杆菌的临床分布特征及耐药趋势分析  

Analysis of Clinical Distribution and Drug-resistance of Acinetobacter Baumannii

作　　者：焦立群[1] 曹晋桂[1] 崔霞[1] 

机构地区：[1]空军总医院感染控制科,北京100036

出　　处：《标记免疫分析与临床》2009年第5期285-288,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：监测医院近年临床标本中鲍曼不动杆菌的分布特点及其耐药情况,以指导临床合理用药。将2004年1月至2008年12月从主要来源于呼吸内科(23.0%)、老年病科(20.0%)、ICU中心(9.9%)、血液科(8.9%)等科室患者的不同标本中分离的鲍曼不动杆菌,采用CLSI/NCCLS标准K-B法分析其对临床常用抗菌药物的耐药情况,用Whonet5.4软件进行统计学分析。结果如下:2004至2008年鲍曼不动杆菌检出率分别为4.4%、4.0%、4.6%、4.6%、4.7%,痰中的检出率最高,为84.1%。该菌耐药现象严重,约60%对哌拉西林、头孢噻肟、氨曲南等呈多重耐药。敏感度最高的是碳青霉烯类,约84.0%。To investigate the clinical distribution and drug-resistance of Acinetobacter baumannii in our hospital in order to provide evidence to proper use of antibiotic drugs in clinics, acinetobacter baumannii isolates were collected in our hospital from Jan 2004 to Dec 2008. Antimicrobial susceptibility testing was performed by disk- diffusion method according to the standards of CL SI/NCCLS. The data were analyzed by WhonetS. 4 software. The results showed that the isolating rate of Acinetobacter baumannii from 2004 to 2008 was 4.4% ,4.0% ,4. 6% ,4.6% and 4.7 % respectively. It was distributed in respiratory ward （23.0%）, Geriatric department （20. 0% ） mainly from ICU （9.9%） and Hematology ward （8.9%）. The highest appearing rate was the sputum,up to 84.1%. More than 60% of isolates were resistant to antimicrobial agents tested such as PIP, CTX and ATM et al. Acinetobacter baumannii showed the highest susceptibility to carbapenem with about 84.0%

关 键 词：鲍曼不动杆菌 抗菌药物 耐药性 院内感染 

分 类 号：R446.5[医药卫生—诊断学]